Collagen: Finding a Solution for the Source
Collagen: Finding a Solution for the Source
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DOI：
10.1089/ten.tea.2012.0721
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发表时间：
2013-07-01
影响因子：
4.1
通讯作者：
Pandit, Abhay
中科院分区：
文献类型：
--
作者：
Browne, Shane;Zeugolis, Dimitrios I.;Pandit, Abhay
基于细胞外基质（Extracellular matrix， ECM）的支架由于其固有的生物活性和分子识别信号，为组织工程和再生应用提供了理想的基质。胶原蛋白是最丰富的ECM蛋白，已被证明是一种非常通用的材料，在许多领域都有应用，包括皮革和食品工业、化妆品、药物输送和组织工程。然而，考虑到与动物来源相关的可能的免疫原性和疾病传播，以及重组技术的生物活性和可用性降低，对组织工程应用的胶原蛋白的最佳来源仍然存在疑问。在这个特别版中，试图阐明植物来源的人重组胶原蛋白的优点及其在组织工程中的应用，特别是皮肤和伤口愈合。虽然结果很有希望，但动物源性胶原蛋白的广泛使用意味着重组技术可能会在利基领域找到应用。
Extracellular matrix (ECM)-based scaffolds, through their inherent bioactivity and molecular recognition signals, provide the ideal substrate for tissue engineering and regenerative applications. Collagen, the most abundant ECM protein, has proven itself to be a very versatile material with applications in many fields, including the leather and food industries, cosmetics, drug delivery, and tissue engineering. However, doubts persist about the optimal source of collagen for tissue engineering applications, given possible immunogenicity and disease transmission associated with animal sources and reduced bioactivity and availability of recombinant technologies. In this special edition, an attempt is made to elucidate the advantages of plant-derived human recombinant collagen and its applications in tissue engineering, particularly skin and wound healing. While results are promising, the widespread use of animal-derived collagen means that recombinant technologies may find applications in niche areas.