Meta-analysis of the association between the inflammatory potential of diet and urologic cancer risk.
Meta-analysis of the association between the inflammatory potential of diet and urologic cancer risk.
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DOI：
10.1371/journal.pone.0204845
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Dong Q
中科院分区：
文献类型：
--
作者：
Lu DL;Ren ZJ;Zhang Q;Ren PW;Yang B;Liu LR;Dong Q
饮食的炎症潜力已被证明与几种癌症类型的风险有关，但关于泌尿系统癌症（UC）的相关风险的证据不一致。因此，我们进行了本荟萃分析，以调查饮食和UC的炎症潜力之间的关联。检索了截至2018年7月31日的PubMed、Embase和Web of Science。两名评审员独立选择研究并提取数据。使用Stata12.0软件包计算合并风险比（RR）及其95%置信区间（CI）。9项病例对照研究和3项队列研究（包括83，197例受试者）符合入选标准。总体荟萃分析结果显示，DII（饮食炎症指数）类别最高的个体与前列腺癌风险增加相关（RR = 1.62，95%CI：1.30-2.02）;亚组分析显示一致的结果。对于肾癌和膀胱癌，在DII评分最高的个体中发现了显著的正相关性;然而，在DII和尿路上皮细胞癌（UCC）的风险之间没有发现显著的相关性。现有数据表明，更多的促炎饮食与前列腺癌、肾癌和膀胱癌的风险增加有关。然而，进一步精心设计的大规模队列研究是必要的，以提供更确凿的证据。
The inflammatory potential of diet has been shown to have an association with the risk of several cancer types, but the evidence is inconsistent regarding the related risk of urologic cancer (UC). Therefore, we conducted the present meta-analysis to investigate the association between the inflammatory potential of diet and UC. PubMed, Embase and Web of Science were searched up to July 31, 2018. Two reviewers independently selected the studies and extracted the data. The pooled risk ratio (RR) and its 95% confidence interval (CI) were calculated using the Stata12.0 software package. Nine case-control studies and three cohort studies including 83,197 subjects met the inclusion criteria. The overall meta-analysis results showed that individuals with the highest category of DII (dietary inflammatory index) were associated with an increased risk of prostate cancer (RR = 1.62, 95% CI: 1.30–2.02); subgroup analysis showed consistent results. For kidney and bladder cancer, significant positive associations were found in individuals with the highest category of DII score; however, no significant association was found between DII and the risk of urothelial cell carcinoma (UCC). Available data suggest that more pro-inflammatory diets are associated with an increased risk of prostate cancer, kidney cancer and bladder cancer. However, further well designed large-scaled cohort studies are warranted to provide more conclusive evidence.