daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
复制标题
DOI：
10.1126/science.277.5328.942
复制
发表时间：
1997-08-15
期刊：
影响因子：
56.9
通讯作者：
Ruvkun, G
中科院分区：
文献类型：
--
作者：
Kimura, KD;Tissenbaum, HA;Ruvkun, G
梭线虫神经分泌信号系统调节动物是否进入生殖生活周期或在长寿命的Dauer滞育阶段停止发育。daf-2是介导这种内分泌信号传导的遗传途径中的关键基因，编码胰岛素受体家族成员。β-2信号的减少诱导代谢和发育变化，如在哺乳动物中胰岛素受体的代谢控制。β-2信号的减少也导致寿命的增加。通过胰岛素样代谢控制的寿命调节类似于通过热量限制诱导的哺乳动物寿命延长，这表明代谢、滞育和寿命之间存在普遍联系。
A C. elegans neurosecretory signaling system regulates whether animals enter the reproductive life cycle or arrest development at the long-lived dauer diapause stage. daf-2, a key gene in the genetic pathway that mediates this endocrine signaling, encodes an insulin receptor family member. Decreases in DAF-2 signaling induce metabolic and developmental changes, as in mammalian metabolic control by the insulin receptor, Decreased DAF-2 signaling also causes an increase in life-span. Life-span regulation by insulin-like metabolic control is analogous to mammalian longevity enhancement induced by caloric restriction, suggesting a general link between metabolism, diapause, and longevity.