Caloric Restriction-Induced Decreases in Dopamine Receptor Availability are Associated with Leptin Concentration
Caloric Restriction-Induced Decreases in Dopamine Receptor Availability are Associated with Leptin Concentration
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DOI：
10.1002/oby.22023
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发表时间：
2017-11-01
期刊：
影响因子：
6.9
通讯作者：
Tamboli, Robyn A.
中科院分区：
文献类型：
--
作者：
Dunn, Julia P.;Abumrad, Naji N.;Tamboli, Robyn A.
ObjectiveIt has been previously reported that early after Roux-en-Y-gastric bypass, dopamine (DA) type 2 and 3 receptor (D2/3R) binding potential (BPND) was decreased from preoperative levels. The current study aimed to determine whether calorie restriction without weight loss modifies D2/3R BPND and whether such changes are explained by neuroendocrine regulation.MethodsFifteen females with obesity (BMI=396 kg/m(2)) were studied before and after approximate to 10 days of a very-low-calorie-diet (VLCD). Outcome measures included fasting insulin, leptin, acyl ghrelin, and glucose, and insulin sensitivity and disposition index were estimated using the oral-minimal model (OMM) method. Participants underwent positron emission tomography scanning with the displaceable radioligand [F-18]fallypride to estimate available regional D2/3R levels. Regions of interest included the caudate, putamen, ventral striatum, hypothalamus, and substantia nigra (SN).ResultsWith the VLCD, weight decreased slightly (-3 kg). Insulin, glucose, and leptin decreased significantly, but there was no change in acyl ghrelin or measures from OMM. SN D2/3R BPND decreased significantly, with trends toward decreased levels in the remaining regions. The decrease in leptin concentration strongly predicted the change in D2/3R BPND in all regions (all P0.004).ConclusionsIn obesity, reductions in regional D2/3R availability after VLCD are suggestive of increased endogenous DA competing with the radioligand. Changes in regional D2/3R availability were associated with decreases in leptin concentrations that occurred before clinically significant weight loss.
