The Prognostic Value of Tumor-infiltrating Lymphocytes in Hepatocellular Carcinoma: a Systematic Review and Meta-analysis
The Prognostic Value of Tumor-infiltrating Lymphocytes in Hepatocellular Carcinoma: a Systematic Review and Meta-analysis
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肿瘤浸润淋巴细胞在肝细胞癌中的预后价值：系统评价和荟萃分析
DOI：
10.1038/s41598-017-08128-1
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发表时间：
2017-08-08
影响因子：
4.6
通讯作者：
Ji, Lei
中科院分区：
文献类型：
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作者：
Yao, Wei;He, Jun-chuang;Ji, Lei
既往临床研究发现，肿瘤浸润淋巴细胞（TIL）水平与肝细胞癌（HCC）的预后显著相关。然而，这些结论和数据仍然存在争议。我们进行了一项系统回顾和荟萃分析，以评估TIL在HCC患者中的预后价值和临床应用。共有23项相关研究的3173例患者被纳入我们的荟萃分析。结果表明，高水平的CD 8+和CD 3 + TIL对总生存期（OS）具有更好的预后价值，HR为0.71（P= 0.04）和0.63（P= 0.03），与低水平相比，高水平的CD 8+、CD 3+和CD 4 + TIL对无疾病/无复发生存期（DFS/RFS）的影响也是如此，HR为0.66（P= 0.01）、0.60（P= 0.01）和0.79（P= 0.04）。相反，高水平FoxP 3 + TIL对OS和DFS/RFS的预后价值更差，HR分别为2.06（P< 0.00001）和1.77（P< 0.00001）。FoxP 3 +/CD 4+和FoxP 3 +/CD 8+比值与OS和DFS/RFS呈负相关。这些发现表明，TIL可以作为HCC的预后生物标志物。然而，TILs在HCC中的临床应用价值有待进一步研究。
Previous clinical studies have found that the levels of tumor-infiltrating lymphocytes (TILs) significantly correlated with prognosis in hepatocellular carcinoma (HCC). However, these conclusions and data remain controversial. We performed a systematic review and meta-analysis to assess the prognostic value and clinical utilization of TILs in patients with HCC. A total of 23 relevant studies of 3173 patients were included into our meta-analysis. The results demonstrated that high levels of CD8+and CD3+TILs had a better prognostic value on overall survival (OS), with HRs of 0.71 (P= 0.04) and 0.63 (P= 0.03), respectively, compared to low levels, as did high levels of CD8+, CD3+and CD4+TILs on disease/recurrence-free survival (DFS/RFS), with HRs of 0.66 (P= 0.01), 0.60 (P= 0.01) and 0.79 (P= 0.04), respectively. In contrast, high levels of FoxP3+TILs had a worse prognostic value on OS and DFS/RFS, with HRs of 2.06 (P< 0.00001) and 1.77 (P< 0.00001), respectively. The FoxP3+/CD4+and FoxP3+/CD8+ratios negatively correlated with OS and DFS/RFS. These findings suggest that TILs may serve as a prognostic biomarker in HCC. However, further research should be performed to clarify the clinical value of TILs in HCC.