Resveratrol reduces oxidative stress and cell death and increases mitochondrial antioxidants and XIAP in PC6.3-cells
Resveratrol reduces oxidative stress and cell death and increases mitochondrial antioxidants and XIAP in PC6.3-cells
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DOI：
10.1016/j.neulet.2010.11.042
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发表时间：
2011-01-25
影响因子：
2.5
通讯作者：
Lindholm, Dan
中科院分区：
文献类型：
--
作者：
Kairisalo, Minna;Bonomo, Alessandra;Lindholm, Dan
白藜芦醇是一种从红葡萄中提取的多酚，已被证明具有多种积极的生物作用，如保护细胞免受氧化应激。它还可以影响细胞信号传导，但其抗氧化特性背后的机制在很大程度上是未知的。在这里，我们发现RSV降低PC6.3细胞的氧化应激并提高细胞存活率取决于浓度。在这些细胞中，RSV增加了抗氧化剂、SOD2和TRX2以及X染色体相关的凋亡抑制蛋白的水平。RSV还激活NF κ B信号，如荧光素酶报告基因结构所示。这些发现表明RSV调节神经元细胞的氧化应激和线粒体抗氧化剂。这可能有助于各种脑部疾病的细胞保护。2010爱思唯尔爱尔兰有限公司版权所有。
Resveratrol, a polyphenol derived e.g. from red grapes, has been shown to mediate several positive biological actions such as protection of cells against oxidative stress. It can also influence cell signaling, but the mechanisms behind its antioxidant properties are largely unknown. Here we show that RSV reduces oxidative stress and enhances cell survival in PC6.3 cells depending on the concentration. In these cells, RSV increased the levels of antioxidants, SOD2 and TRX2, and of X chromosome-linked inhibitor of apoptosis protein. RSV also activated NF kappa B signaling as shown using luciferase reporter constructs. These findings show that RSV regulates oxidative stress and mitochondrial antioxidants in neuronal cells. This may contribute to cell protection in various brain disorders. (C) 2010 Elsevier Ireland Ltd. All rights reserved.