Anti-gastric ulcer effect of Kaempferia parviflora
Anti-gastric ulcer effect of Kaempferia parviflora
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DOI：
10.1016/j.jep.2005.03.035
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发表时间：
2005-10-31
影响因子：
5.4
通讯作者：
Pojanagaroon, S
中科院分区：
文献类型：
--
作者：
Rujjanawate, C;Kanjanapothi, D;Pojanagaroon, S
小花山奈是一种姜科植物，因其有益的药用功效而闻名。本研究旨在通过实验模型评估小花山奈乙醇提取物 (KPE) 的抗胃溃疡活性。口服30、60和120 mg/kg KPE可显着抑制大鼠吲哚美辛、HCl/EtOH和水浸约束应激诱导的胃溃疡形成。在幽门结扎大鼠中，KPE 预处理对胃容量、pH 和酸度输出没有影响。在乙醇诱导的溃疡大鼠中，60 和 120 毫克/千克剂量的 KPE 预处理显着保留了胃壁粘液，但 30 毫克/千克剂量则不然。研究结果表明，小花山柰的乙醇提取物具有胃保护潜力，部分与保留胃粘液分泌有关，与抑制胃酸分泌无关。 (C) 2005 Elsevier Ireland Ltd. 保留所有权利。
Kaempferia parviflora is a Zingiberaceous plant, which has been reputed for its beneficial medicinal effects. The present study was undertaken to evaluate the Kaempferia parviflora ethanolic extract (KPE) for its anti-gastric ulcer activity by experimental models. Oral administration of the KPE at 30, 60 and 120 mg/kg significantly inhibited gastric ulcer formation induced by indomethacin, HCl/EtOH and water immersion restraint-stress in rats. In pylorus-ligated rats, pretreatment with the KPE had no effect on gastric volume, pH and acidity output. In ethanol-induced ulcerated rats, gastric wall mucus was significantly preserved by the KPE pretreatment at doses of 60 and 120 but not at 30 mg/kg. The findings indicate that the ethanolic extract of Kaempferia parviflora possesses gastroprotective potential which is related partly to preservation of gastric mucus secretion and unrelated to the inhibition of gastric acid secretion. (C) 2005 Elsevier Ireland Ltd. All rights reserved.