PD-1 genotype of the donor is associated with acute graft-versus-host disease after HLA-identical sibling donor stem cell transplantation
PD-1 genotype of the donor is associated with acute graft-versus-host disease after HLA-identical sibling donor stem cell transplantation
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DOI：
10.1007/s00277-018-3438-y
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发表时间：
2018-11-01
影响因子：
3.5
通讯作者：
Gallardo, David
中科院分区：
文献类型：
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作者：
Santos, Nazly;Rodriguez-Romanos, Rocio;Gallardo, David
程序性死亡1(PD-1)的激活触发了一个免疫检查点，导致抑制T细胞，从而导致外周耐受。一些PD-1基因多态性已被描述并与自身免疫性疾病或癌症易感性的发生有关，但关于这些基因多态性与异基因造血干细胞移植(Allo HSCT)后临床结果的相关性的数据很少。我们分析了1485例人类白细胞抗原相合的同胞供者的Pd-1.1G/A(Rs36084323)和Pd-1.3G/A(Rs11568821)SNPs的分布。我们发现，接受rs36084323SNP G等位基因纯合子的患者和rs11568821位置的A等位基因纯合子的捐赠者，发生II级至IV级移植物抗宿主病的风险增加(P=0.033；风险比[HR]2.2；95%可信区间[CI]1.1至4.8)。
Programmed death 1 (PD-1) activation triggers an immune checkpoint resulting in inhibition of T cells that leads to peripheral tolerance. Some PD-1 polymorphisms have been described and associated with the development of autoimmune diseases or cancer predisposition, but there are few data concerning the relevance of such polymorphisms on the clinical outcome after allogeneic hematopoietic stem cell transplant (alloHSCT). We analyzed the distribution of the SNPs PD-1.1G/A (rs36084323) and PD-1.3G/A (rs11568821) genotypes of the donor in a cohort of 1485 alloHSCT from HLA-identical sibling donors. We found an increased risk of grades II to IV graft-versus-host disease (GvHD) in patients receiving grafts from donors homozygous for the G allele at the rs36084323 SNP (P=0.033; hazard ratio [HR] 2.2; 95% confidence interval [CI] 1.1 to 4.8) and also from donors homozygous for the A allele at the rs11568821 position (P