Cigarette smoking and cognitive decline in midlife: Evidence from a prospective birth cohort study
Cigarette smoking and cognitive decline in midlife: Evidence from a prospective birth cohort study
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DOI：
10.2105/ajph.93.6.994
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发表时间：
2003-06-01
影响因子：
12.7
通讯作者：
Wadsworth, MEJ
中科院分区：
文献类型：
--
作者：
Richards, M;Jarvis, MJ;Wadsworth, MEJ
目标。作者调查了吸烟对中年认知能力的影响。研究人员使用多元回归来测试吸烟与认知测试分数变化之间的关系，研究对象是1946年出生在英国的43岁至53岁的男性和女性。吸烟与语言记忆的快速下降和视觉搜索速度的减慢有关。这些影响在很大程度上是由每天吸烟超过20支的个体造成的，并且与性别、社会经济地位、以前（青少年）的认知能力和一系列健康指标无关。目前的研究结果表明，大量吸烟与认知障碍和中年衰退有关。吸烟者如果活到晚年，可能会有临床上显著的认知能力下降的风险。
Objectives. The authors investigated the effects of cigarette smoking on midlife cognitive performance.Methods. Multiple regression was used to test the association between cigarette smoking and changes in cognitive test scores among male and female members of the British 1946 birth cohort aged between 43 and 53 years.Results. Smoking was associated with faster declines in verbal memory and with slower visual search speeds. These effects were largely accounted for by individuals who smoked more than 20 cigarettes per day and were independent of sex, socioeconomic status, previous (adolescent) cognitive ability, and a range of health indicators.Conclusions. The present results show that heavy smoking is associated with cognitive impairment and decline in midlife. Smokers who survive into later life may be at risk of clinically significant cognitive declines.