Distribution Pattern of Urine Albumin Creatinine Ratio and the Prevalence of High-Normal Levels in Untreated Asymptomatic Non-Diabetic Hypertensive Patients
Distribution Pattern of Urine Albumin Creatinine Ratio and the Prevalence of High-Normal Levels in Untreated Asymptomatic Non-Diabetic Hypertensive Patients
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DOI：
10.2169/internalmedicine.50.5075
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发表时间：
2011-01-01
影响因子：
1.2
通讯作者：
Kusachi, Shozo
中科院分区：
文献类型：
--
作者：
Ohmaru, Natsuki;Nakatsu, Takaaki;Kusachi, Shozo
背景 据报道，即使是高正常白蛋白尿也与心血管事件相关。 目的 我们测定了点尿样本中的尿白蛋白肌酐比 (UACR)，并分析了 UACR 分布和高正常水平的发生率。 患者和方法 使用免疫比浊法测定 332 名未经治疗的无症状非糖尿病日本高血压患者和 69 名对照受试者中的 UACR。微量白蛋白尿和大量白蛋白尿水平分别定义为 UCAR >= 30 和 = 300 μ g/mg.肌酐。 结果 分布模式显示较低水平的高度偏态分布，并且常见的对数变换产生与高斯分布的紧密拟合，其中中位数、第 25 个百分位数和第 75 个百分位值分别为 22.6、13.5 和 48.2 mu 分别为g/mg.肌酐。当正常高值 UACR 设置为 >20 时
Background Even high-normal albuminuria is reportedly associated with cardiovascular events.Objective We determined the urine albumin creatinine ratio (UACR) in spot urine samples and analyzed the UACR distribution and the prevalence of high-normal levels.Patients and Methods The UACR was determined using immunoturbidimetry in 332 untreated asymptomatic non-diabetic Japanese patients with hypertension and in 69 control subjects. The microalbuminuria and macroalbuminuria levels were defined as a UCAR >= 30 and = 300 mu g/mg.creatinine, respectively.Results The distribution patterns showed a highly skewed distribution for the lower levels, and a common logarithmic transformation produced a close fit to a Gaussian distribution with median, 25th and 75th percentile values of 22.6, 13.5 and 48.2 mu g/mg.creatinine, respectively. When a high-normal UACR was set at >20 to