Vinylaluminum addition to sulfinimines (N-sulfinyl imines). Asymmetric synthesis of anti-alpha-alkyl beta-amino esters.
Vinylaluminum addition to sulfinimines (N-sulfinyl imines). Asymmetric synthesis of anti-alpha-alkyl beta-amino esters.
复制标题
乙烯基铝与亚磺酰亚胺（N-亚磺酰亚胺）相加。
DOI：
10.1021/jo9001504
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Gaddiraju,NarendraV
中科院分区：
文献类型：
--
作者：
Davis,FranklinA;Qiu,Hui;Song,Minsoo;Gaddiraju,NarendraV
Addition of vinylaluminum NMO reagents toN-(p-toluenesufinyl)- andN-(2-methypropanesulfinyl)-derived sulfinimines givesN-sulfinyl aza-Morita−Baylis−Hillman products (dr = 7:1 to 12:1) that result from addition of the reagent from the least hindered direction. Hydrogenation of the aza-MBH adducts with a Rh(I) catalyst affordsanti-α-substitutedN-sulfinyl-β-amino esters in good yield and high dr (10:1 to 21:1).
