DNA METHYLATION IN EUKARYOTES
DNA METHYLATION IN EUKARYOTES
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DOI：
10.1016/0959-437x(95)80014-x
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发表时间：
1995-04-01
影响因子：
4
通讯作者：
RICHARDS, EJ
中科院分区：
文献类型：
--
作者：
MARTIENSSEN, RA;RICHARDS, EJ
最近的进展扩大了我们对真核生物中 DNA 甲基化模式的建立、维持和阐述过程的理解。通过比较不同真核生物中各种表观遗传现象的结果来寻找 DNA 甲基化的功能意义。最近在小鼠、链孢霉和拟南芥中开发的 DNA 甲基化突变体将使传统的基因解剖能够应用于解决有关真核 DNA 甲基化的功能和调节的长期存在的问题。尽管甲基化似乎对于维持不同的表观遗传状态很重要，但建立这些状态的机制可能涉及其他过程。
Recent advances have expanded our understanding of the processes underlying the establishment, maintenance, and elaboration of DNA methylation patterns in eukaryotes. The functional significance of DNA methylation is sought in a comparison of results on a variety of epigenetic phenomena in different eukaryotes. The recent development of DNA methylation mutants in mice, Neurospora, and Arabadopsis will allow traditional genetic dissection to be applied to long-standing problems regarding the function and regulation of eukaryotic DNA methylation. Although methylation appears to be important for maintenance of different epigenetic states, the mechanism that establishes these states is likely to involve additional processes.