Association between growth differentiation factor 5 rs143383 genetic polymorphism and the risk of knee osteoarthritis among Caucasian but not Asian: a meta-analysis
Association between growth differentiation factor 5 rs143383 genetic polymorphism and the risk of knee osteoarthritis among Caucasian but not Asian: a meta-analysis
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生长分化因子 5 rs143383 基因多态性与白种人而非亚洲人膝骨关节炎风险之间的关联：一项荟萃分析
DOI：
10.1186/s13075-020-02306-9
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发表时间：
2020-09-14
影响因子：
4.9
通讯作者：
Wang, Peng
中科院分区：
文献类型：
--
作者：
Peng, Lei;Jin, Song;Wang, Peng
几个月前，《生物科学报告》杂志报道，生长分化因子5 (GDF5) rs143383基因多态性增加了膝关节骨关节炎（KOA）的易感性，但之前的研究结果对现有数据存在争议。考虑到近期数据的可用性，我们重点通过病例对照试验数据的荟萃分析来阐明KOA与GDF5 rs143383遗传多态性的关系。方法从PubMed、施普林格、Cochrane图书馆、Web of Science、中国知网（CNKI）、万方图书馆等数据库收集建库时间至2019年10月的符合条件的研究。比值比（OR）和95%置信区间（CI）用于估计这些多态性与KOA风险之间的关联。meta分析采用STATA 18.0软件完成。结果共纳入196项研究，其中16项纳入最终荟萃分析（7997例，12684例对照）。在所有遗传模型中，GDF5 rs143383多态性与KOA之间存在显著相关性(等位基因模型（C对T）： OR = 0.84 (95% CI = 0.76-0.91)；主导模型（CC+CT vs . TT）： OR = 0.80 (95% CI = 0.72-0.90)；隐性模型（CC vs CT+TT）： OR = 0.79 (95% CI = 0.68-0.92)；杂合子模型（CT vs CC+TT）： OR = 0.89 (95% CI = 0.80-0.97)；纯合子模型（CC vs TT）： OR = 0.71 （95% CI = 0.60-0.85）。在亚组分析中，我们得到的结果是在亚洲人中没有显著性。结论GDF5 rs143383基因多态性增加白种人KOA发病风险；CC基因型和C等位基因是白种人KOA易感性的保护因素。
Background A few months ago, theBioscience Reportsjournal showed that growth differentiation factor 5 (GDF5) rs143383 genetic polymorphism increases the susceptibility of knee osteoarthritis (KOA), but previous studies' results have debates about available data. Considering the availability of more recent data, we focus on clarifying the relationship of KOA and GDF5 rs143383 genetic polymorphism by a meta-analysis of case-control trial data. Methods The eligible studies from the time of database established to Oct. 2019 were collected from PubMed, Springer, Cochrane library, Web of Science, China National Knowledge Infrastructure (CNKI), and Wan Fang library. Odds ratios (OR) and 95% confidence intervals (CI) were used to estimate the association between these polymorphisms and KOA risk. The meta-analysis was completed by STATA 18.0 software. Results A total of 196 studies were collected, 16 of them included in final meta-analysis (7997 cases and 12,684 controls). There was significant association between GDF5 rs143383 polymorphism and KOA in all genetic models (for Allele model (C versus T): OR = 0.84 (95% CI = 0.76-0.91); dominate model (CC+CT versus TT): OR = 0.80 (95% CI = 0.72-0.90); recessive model (CC versus CT+TT): OR = 0.79 (95% CI = 0.68-0.92); heterozygote model (CT versus CC+TT): OR = 0.89 (95% CI = 0.80-0.97); homozygous model (CC versus TT): OR = 0.71 (95% CI = 0.60-0.85)). In the subgroup analysis, we obtained the results that there is no significance among Asians. Conclusion GDF5 rs143383 genetic polymorphism increases the risk of KOA among Caucasians; CC genotype and C allele are protective factors for the susceptibility of KOA among Caucasians.