An equine joint friction test model using a cartilage-on-cartilage arrangement
An equine joint friction test model using a cartilage-on-cartilage arrangement
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DOI：
10.1016/j.tvjl.2008.12.003
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发表时间：
2010-02-01
影响因子：
2.2
通讯作者：
Serteyn, Didier
中科院分区：
文献类型：
--
作者：
Noble, Prisca;Collin, Bernard;Serteyn, Didier
本研究描述了使用软骨对软骨排列的马关节摩擦试验，并研究了年龄和载荷对摩擦响应的影响。从马肩关节（2-5岁，n = 12； 10-14岁，n = 15）中取出骨软骨塞，并安装在针盘摩擦计中。然后在恒定条件下（2 N、20℃、5 mm/s）和增加载荷（2 N、5 N、10 N）测量摩擦响应。在所有实验中，年轻软骨的摩擦系数显著（P < 0.001）小于年老软骨，而施加更大的载荷导致只有年老软骨的摩擦系数显著（P < 0.001）降低。在这些实验条件下，软骨老化是摩擦系数增加的主要原因。此外，在年轻软骨润滑保持稳定的地方，软骨老化可能是润滑制度改变的原因。软骨对软骨模型可以更好地了解健康和患病马关节的润滑状态紊乱，并测试各种生物润滑剂治疗的效果。(C) 2008 Elsevier Ltd版权所有。
This study describes an equine joint friction test using a cartilage-on-cartilage arrangement and investigates the influence of age and load on the frictional response. Osteochondral plugs were extracted from equine shoulder joints (2-5 years, n = 12; 10-14 years, n = 15), and mounted in a pin-on-disc tribometer. The frictional response was then measured under constant conditions (2 N; 20 degrees C; 5 mm/s), and with increasing load (2 N, 5 N, 10 N). In all experiments, the friction coefficient of young cartilage was significantly (P < 0.001) smaller than obtained from old cartilage, while the application of a greater load resulted in a significant (P < 0.001) decrease in friction coefficient only in old cartilage. It was concluded that cartilage ageing was responsible for an increase in friction coefficient under these experimental conditions. Moreover, where young cartilage lubrication remained stable, cartilage ageing may have been responsible for lubrication regime change. The cartilage-on-cartilage model could be used to better understand lubrication regime disturbances in healthy and diseased equine joints, and to test the efficacy of various bio-lubricant treatments. (C) 2008 Elsevier Ltd. All rights reserved.