The effects of nifedipine, a calcium antagonist, on platelet function.
The effects of nifedipine, a calcium antagonist, on platelet function.
复制标题
硝苯地平（一种钙拮抗剂）对血小板功能的影响。
DOI：
10.1016/0002-8703(83)90285-5
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发表时间：
1983
影响因子：
4.8
通讯作者：
E. Myhre
中科院分区：
文献类型：
--
作者：
J. Dale;K. Landmark;E. Myhre
本文测定了20例冠心病患者服用新型钙拮抗剂硝苯地平20 mg前和服药后1小时的血小板功能。血小板计数保持不变。当使用0.9或3.6毫升血液时，血小板粘附性(用Hellem方法测量的天然血在玻璃珠柱中的保留率)也没有显著下降。在富含柠檬酸的血浆中诱导了依赖于细胞外钙的血小板聚集。用三种不同浓度的二磷酸腺苷引发的平均最大聚集速率降低了20%~26%。硝苯地平治疗后，胶原诱导的不可逆聚集率平均降低23%。服药后平均出血时间延长36秒，或12%。硝苯地平适度但显著地减少血小板聚集和延长出血时间可能是通过抑制血小板膜上钙离子转运而实现的。
Platelet function was studied before and 1 hour after ingestion of 20 mg nifedipine, a new calcium antagonist, in 20 patients with coronary heart disease. Platelet counts remained unchanged. Platelet adhesiveness, measured as retention in glass bead columns with hellem's method for native blood, did not drop significantly either when 0.9 or 3.6 ml of blood was used. Platelet aggregation, which is dependent on extracellular calcium, was induced in citrated platelet-rich plasma. The mean maximal rate of primary aggregation, initiated with three different concentrations of adenosine diphosphate, was reduced by 20% to 26%. The rate of irreversible collagen-induced aggregation was on average 23% lower after nifedipine. The mean bleeding time was 36 seconds, or 12%, longer after ingestion of the drug. The moderate, but significant reduction of platelet aggregation and prolongation of the bleeding time by nifedipine may be mediated through inhibition of calcium transport across the platelet membrane.