Effects of very low birthweight on brain structure in adulthood
Effects of very low birthweight on brain structure in adulthood
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DOI：
10.1017/s0012162204000088
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发表时间：
2004-01-01
影响因子：
3.8
通讯作者：
Murray, R
中科院分区：
文献类型：
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作者：
Allin, M;Henderson, M;Murray, R
极低出生体重(VLBW)的人在围产期脑损伤的风险很高。我们希望确定这种早期的大脑损伤如何影响成年后的大脑结构。32名VLBW成人(20名女性，12名男性)和18名足月正常出生体重的同胞对照组(9名女性，9名男性)接受了结构性MRI检查，平均年龄23岁零4个月(范围17~33岁；SD 3.4)。使用自动组织分割算法对图像进行分析，以估计自然空间中的整个脑组织类别体积。然后将图像扭曲为标准空间中的模板图像。在全脑、灰质、白质或总脑脊液(CSF)体积方面，两组之间没有显著差异。然而，VLBW患者的侧脑室容量显著增加了41%。极低出生体重者脑灰质与白质的比例也显著增加(增加10%)。组比较图显示，极低出生体重儿大脑中灰质和白质的分布以及脑室脑脊液的相对过剩发生了广泛的变化。脑室容量增加预示皮质下核团和边缘皮质结构灰质减少，脑室周围白质减少。我们的结论是，这些弥漫性灰质和白质异常是围产期脑损伤和正在进行的神经发育过程相互作用的结果。
Very-low-birthweight (VLBW) individuals are at high risk of brain injury in the perinatal period. We wished to determine how such early brain lesions affect brain structure in adulthood. Thirty-two VLBW adults (20 female, 12 male) and, 18 term, normal birthweight sibling control individuals (nine female, nine male) underwent structural MRI at a mean age of 23 years 4 months (range 17 to 33 years; SD 3.4). Images were analyzed using an automated tissue segmentation algorithm in order to estimate whole brain tissue class volumes in native space. Images were then warped to a template image in standard space. There was no significant between-group difference in whole brain, greymatter, white matter, or total cerebral spinal fluid (CSF) volumes. However, lateral ventricular volume was significantly increased by 41% in those with VLBW. The ratio of grey to white matter was also significantly increased (by 10%) in those with VLBW. Group comparison maps showed widespread changes in the distribution of grey and white matter, and relative excess of ventricular CSF, in the brains of VLBW individuals. Increased ventricular volume predicted decreased grey matter in subcortical nuclei and limbic cortical structures, and decreased periventricular white matter. We conclude that these diffuse abnormalities of grey and white matter are a consequence,of the interaction of perinatal brain injury and ongoing neurodevelopmental processes.