Eradication of H. pylori Infection in Patients Allergic to Penicillin Using Triple Therapy with a PPI, Metronidazole and Sitafloxacin
Eradication of H. pylori Infection in Patients Allergic to Penicillin Using Triple Therapy with a PPI, Metronidazole and Sitafloxacin
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DOI：
10.2169/internalmedicine.53.1677
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发表时间：
2014-01-01
影响因子：
1.2
通讯作者：
Umemura, Kazuo
中科院分区：
文献类型：
--
作者：
Furuta, Takahisa;Sugimoto, Mitsushige;Umemura, Kazuo
螺杆菌根除对青霉素过敏的患者应使用不含青霉素衍生物的治疗方案。我们用质子泵抑制剂（PPI）、甲硝唑（250 mg bid）和西他布汀（100 mg bid）治疗了28例青霉素过敏患者，持续1 - 2周。在治疗后4 - 8周，患者接受[C-13]-尿素呼气试验。总根除率为100.0%。观察到轻度不良事件。PPI、甲硝唑和西他布汀三联疗法耐受性良好，可有效根除H。对青霉素过敏的患者中的幽门螺杆菌。
Eradication of H. pylori in patients allergic to penicillin should be performed using regimens without penicillin derivatives. We treated a total of 28 patients allergic to penicillin with a proton pump inhibitor (PPI), metronidazole (250 mg bid) and sitafloxacin (100 mg bid) for one to two weeks. At four to eight weeks after the treatment, the patients underwent the [C-13]-urea breath test. The overall eradication rate was 100.0%. Mild adverse events were observed. Triple therapy with a PPI, metronidazole and sitafloxacin is well tolerated and effective for the eradication of H. pylori in patients allergic to penicillin.