Palladium(II)-catalyzed synthesis of functionalized indenes from o-alkynylbenzylidene ketones.
Palladium(II)-catalyzed synthesis of functionalized indenes from o-alkynylbenzylidene ketones.
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DOI：
10.1021/jo1023574
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发表时间：
2011-01
期刊：
影响因子：
--
通讯作者：
F. Zhou;Xiuling Han;Xiyan Lu
中科院分区：
文献类型：
--
作者：
F. Zhou;Xiuling Han;Xiyan Lu
研究了钯催化邻炔基苯亚甲基酮合成功能化茚的新方法。该反应由炔的反式核钯化引发，然后通过共轭加成和通过碳-钯键的质子分解淬灭。以醋酸根和卤离子为亲核试剂，可以高产率地得到3-乙酰氧基和3-卤代茚。
An efficient method for the synthesis of functionalized indenes from o-alkynylbenzylidene ketones under palladium(II) catalysis was developed. The reaction is initiated by trans-nucleopalladation of alkynes, followed by conjugate addition and quenched by protonolysis of the carbon-palladium bond. With acetate and halide ions as nucleophiles, 3-acetoxy- and 3-halogen-substituted indenes could be obtained in high yields.