A DESCRIPTIVE STUDY OF THE BLOOD-VESSELS OF THE SCIATIC-NERVE IN THE RAT, MAN AND OTHER MAMMALS
A DESCRIPTIVE STUDY OF THE BLOOD-VESSELS OF THE SCIATIC-NERVE IN THE RAT, MAN AND OTHER MAMMALS
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DOI：
10.1093/brain/107.3.871
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发表时间：
1984-01-01
期刊：
影响因子：
14.5
通讯作者：
WEDDELL, AGM
中科院分区：
文献类型：
--
作者：
BELL, MA;WEDDELL, AGM
用注射、解剖、显微放射照相、碱性磷酸酶染色厚切片和半薄切片以及电子显微镜等方法，研究了大鼠（以及包括人在内的其他哺乳动物）坐骨神经的总血供和内部血管组织。在所有研究的物种中，神经的微血管网络具有异常大的口径和宽的间距，特别是与骨骼肌相比时。小动脉和小静脉存在于束内;小动脉是薄壁的，只有不发达的内部弹性层。神经内膜毛细血管大，连续，无孔，有突出的（通常是多个）基底层和异常完整的周细胞包埋。内皮连接的类型似乎各不相同;并非所有连接都是紧密的。胞饮作用很常见。神经束广泛互连的血管网络可能充当血液的适应性原位储存库，精确维持神经内膜环境。
The gross blood supply and internal vascular organization of the sciatic nerve in the rat (and other mammals including man) have been studied by injection, dissection, and microradiographic methods, in thick sections stained for alkaline phosphatase and semithin sections, and by electron microscopy.In the rat, an anastomotic vascular connection from the arteria comitans to the medial femoral circumflex artery is illustrated. In all species studied, the microvascular network of the nerve has an unusually large calibre and wide spacing, particularly when compared with that of skeletal muscle. Arterioles and venules are present within fascicles; the arterioles are thin-walled, with only rudimentary internal elastic laminae. Endoneurial capillaries are large, continuous and nonfenestrated, with prominent (often multiple) basal laminae and an unusually complete pericyte investment. Endothelial junctions appear to vary in type; not all are tight. Pinocytosis is common.The extensively interconnected vascular network of the nerve fascicle may act as an adaptable in situ reservoir for blood in the precise maintenance of the endoneurial milieu.