IRON PROMOTERS OF THE FENTON REACTION AND LIPID-PEROXIDATION CAN BE RELEASED FROM HEMOGLOBIN BY PEROXIDES
IRON PROMOTERS OF THE FENTON REACTION AND LIPID-PEROXIDATION CAN BE RELEASED FROM HEMOGLOBIN BY PEROXIDES
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DOI：
10.1016/0014-5793(86)80626-3
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发表时间：
1986-06-09
期刊：
影响因子：
3.5
通讯作者：
GUTTERIDGE, JMC
中科院分区：
文献类型：
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作者：
GUTTERIDGE, JMC
过氧化氢和有机氢过氧化物与血红蛋白反应释放铁，铁可以与脱铁转铁蛋白、博来霉素和去铁胺络合。该释放的铁通过芬顿反应促进脱氧核糖降解，在博来霉素存在下促进DNA降解，并刺激脂质过氧化。在芬顿反应中，从血红蛋白中释放的铁可能是羟基自由基的真正产生者。羟基自由基脂质过氧化转铁蛋白铁结合血红素-蛋白铁释放血红蛋白芬顿催化剂去铁草胺博莱霉素可检测铁
Hydrogen peroxide and organic hydroperoxides react with haemoglobin to release iron which can be complexed to apotransferrin, bleomycin and desferrioxamine. This released iron promotes deoxyribose degradation by a Fenton reaction, DNA degradation in the presence of bleomycin and stimulates lipid peroxidation. It is likely that iron released from haemoglobin is the true generator of hydroxyl radicals in the Fenton reaction.Hydroxyl radicalLipid peroxidationTransferrin iron bindingHeme-protein iron releaseHemoglobin Fenton catalystDesferrioxamineBleomycin-detectable iron