Recognition of telomeric DNA
Recognition of telomeric DNA
复制标题
DOI：
10.1016/s0968-0004(97)01008-6
复制
发表时间：
1997-02-01
影响因子：
13.8
通讯作者：
Rhodes, D
中科院分区：
文献类型：
--
作者：
Konig, P;Rhodes, D
酵母端粒结合蛋白 RAP1 与 DNA 复合的三维结构首次深入了解端粒 UNA 识别，RAP1 通过两个 Myb/同源结构域样基序与 DNA 结合，这些基序是先前在转录因子中识别的 DNA 结合折叠，再加上人类 TRF1 和其他端粒结合因子含有 Myb 样基序的发现，使我们推测保守的蛋白折叠可能用于端粒 DNA认可。
The three-dimensional structure of the yeast telomere-binding protein RAP1 in complex with DNA provides the first insight into telomeric UNA recognition, RAP1 binds to DNA via two Myb/homeodomain-like motifs, which are DNA-binding folds previously identified in transcription factors, This, together with the finding that human TRF1 and other telomere-binding factors contain Myb-like motifs, has led us to speculate that a conserved protein fold might be used for telomeric DNA recognition.