The family of bone morphogenetic proteins
The family of bone morphogenetic proteins
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DOI：
10.1046/j.1523-1755.2000.00081.x
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发表时间：
2000-06-01
影响因子：
19.6
通讯作者：
Karsenty, G
中科院分区：
文献类型：
--
作者：
Ducy, P;Karsenty, G
骨形态发生蛋白（BMP）是属于生长因子的转化生长因子-β（TGF-β）超家族的分泌信号分子。第一批BMP最初是通过植入啮齿动物皮肤下时诱导异位骨形成的能力来鉴定的。在这种异位过表达试验中，有一个重演的所有事件发生在骨骼发生。后者表明这些分子在发育过程中可能发挥重要作用。迄今为止，已经确定了30多种BMP。对它们的表达模式的研究以及对自发突变或遗传缺失小鼠的分析已经证明了更广泛的功能。这些活性主要位于上皮-间充质相互作用的位点，包括但不限于骨骼。本文综述了骨形态发生蛋白在骨骼发育和其他生物学过程中的作用。
Bone morphogenetic proteins (BMPs) are secreted signaling molecules belonging to the transforming growth factor-beta (TGF-beta) superfamily of growth factors. The first BMPs were originally identified by their ability to induce ectopic bone formation when implanted under the skin of rodents. In this ectopic overexpression assay, there was a recapitulation of all the events occurring during skeletogenesis. This latter aspect indicated that these molecules could play important roles during development. More than 30 BMPs have been identified to date. The study of their expression pattern as well as the analysis of spontaneously mutated or genetically depleted mice have demonstrated a much broader range of function. These activities are mainly localized at sites of epithelial-mesenchymal interactions, including but not restricted to the skeleton. This review presents our current knowledge about the functions of BMPs during skeleton development as well as in many other biologic processes.