Emotional states and future risk of venous thromboembolism The Tromso Study
Emotional states and future risk of venous thromboembolism The Tromso Study
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DOI：
10.1160/th11-09-0667
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发表时间：
2012-03-01
影响因子：
6.7
通讯作者：
Hansen, John-Bjarne
中科院分区：
文献类型：
--
作者：
Enga, Kristin F.;Braekkan, Sigrid K.;Hansen, John-Bjarne
据报道，抑郁和孤独的情绪状态与动脉性心血管疾病（CVD）和死亡风险较高和乐观情绪较低相关。情绪状态与静脉血栓栓塞（VTE）风险之间的关系此前尚未被探讨。我们的目的是在一项基于人群的前瞻性研究中调查自我报告的情绪状态与突发静脉血栓栓塞风险之间的关系。在1994-1995年特罗姆瑟研究中，25,964名年龄在25-96岁之间的研究对象通过自我管理的问卷记录了抑郁、孤独和快乐/乐观的频率，以及主要的共病和生活习惯。事件vte事件从纳入之日起至2007年9月1日登记。在平均12.4年的随访期间，共发生440例静脉血栓栓塞事件。在调整了其他危险因素（年龄、性别、体重指数、雌激素）、生活方式（吸烟、饮酒、教育水平）和合病（糖尿病、心血管疾病和癌症）后，经常感到抑郁的受试者患静脉血栓栓塞的风险比不抑郁的受试者高1.6倍（95% CI:1.02-2.50）。经常感到孤独与VIE无关。然而，经常感到孤独和抑郁的受试者VIE的发病率高于单独抑郁的受试者（年龄和性别调整后的发病率：3.27比2.21）。相反，经常感到快乐/乐观的受试者患VIE的风险降低40% （HR 0.60, 95% CI: 0.41-0.87）。我们的研究结果表明，自我报告的情绪状态与VIE的风险有关。抑郁情绪会增加患静脉血栓栓塞的风险，而快乐/乐观则会降低患静脉血栓栓塞的风险。
Emotional states of depression and loneliness are reported to be associated with higher risk and optimism with lower risk of arterial cardiovascular disease (CVD) and death. The relation between emotional states and risk of venous thromboembolism (VTE) has not been explored previously. We aimed to investigate the associations between self-reported emotional states and risk of incident VTE in a population-based, prospective study. The frequency of feeling depressed, lonely and happy/optimistic were registered by self-administered questionnaires, along with major co-morbidities and lifestyle habits, in 25,964 subjects aged 25-96 years, enrolled in the Tromso Study in 1994-1995. Incident VTE-events were registered from the date of inclusion until September 1, 2007. There were 440 incident VTE-events during a median of 12.4 years of follow-up. Subjects who often felt depressed had 1.6-fold (95% CI:1.02-2.50) higher risk of VTE compared to those not depressed in analyses adjusted for other risk factors (age, sex, body mass index, oestrogens), lifestyle (smoking, alcohol consumption, educational level) and co-morbidities (diabetes, CVD, and cancer). Often feeling lonely was not associated with VIE. However, the incidence rate of VIE in subjects who concurrently felt often lonely and depressed was higher than for depression alone (age-and sex-adjusted incidence rate: 3.27 vs. 2.21). Oppositely, subjects who often felt happy/optimistic had 40% reduced risk of VIE (HR 0.60, 95% CI: 0.41-0.87). Our findings suggest that self-reported emotional states are associated with risk of VIE. Depressive feelings were associated with increased risk, while happiness/optimism was associated with reduced risk of VTE.