Mold burden in house dust and its relationship with asthma control.
Mold burden in house dust and its relationship with asthma control.
复制标题
DOI：
10.1016/j.rmed.2019.02.014
复制
发表时间：
2019-04
影响因子：
4.3
通讯作者：
P. Segura-Medina;M. H. Vargas;José M. Aguilar‐Romero;J. L. Arreola-Ramírez;J. L. Miguel-Reyes;J. Salas-Hernández
中科院分区：
文献类型：
--
作者：
P. Segura-Medina;M. H. Vargas;José M. Aguilar‐Romero;J. L. Arreola-Ramírez;J. L. Miguel-Reyes;J. Salas-Hernández
一些证据表明，暴露于霉菌或其产品可能与哮喘控制的丧失有关。因此，我们测量了霉菌负担的受试者与哮喘的房屋内，并评估其与哮喘control.MethodsMarkers居住在墨西哥城的成年患者的哮喘控制的关系进行了评估，通过问卷调查和肺功能测定。从患者的房屋和灰尘收集真菌含量测定霉菌特异性定量PCR（MSQPCR）为36真菌species.Results42例哮喘患者（12男，30女），平均年龄为45岁（18-76岁）被列入本研究。通过哮喘控制测试测量的哮喘控制水平范围为9至25（平均20.9）。FEV 1/FVC比值在38 - 106%预测值范围内波动（平均值，87.4%预测值）。霉菌负荷和哮喘控制之间的关联在男性和女性之间存在差异。因此，浓度的一些霉菌，特别是Aspergillusfumigatus，Aureobasidiumpullulans，Stachybocyanchartarum，Alternaria alternata，Cladosporiumcladosporioides 2，Cladosporiumherbarum，和Epicoccumnigrum，与男性受试者的哮喘控制参数呈负相关，但不是在女性patients.ConclusionOur结果表明，潜在的室内暴露于一些霉菌与男性受试者的哮喘控制较少。
ObjectiveSome evidences indicate that exposure to molds or their products can be relevant for the loss of asthma control. Thus, we measured the mold burden present inside houses of subjects with asthma, and evaluated its relationship with asthma control.MethodsMarkers of asthma control in adult patients residing in Mexico City were evaluated through questionnaires and spirometry. Dust was collected from the patients’ houses and its fungal content was determined by mold specific quantitative PCR (MSQPCR) for 36 fungal species.ResultsForty-two patients with asthma (12 males, 30 females) with a mean age of 45 years (18–76 years) were included in the study. The level of asthma control measured through the Asthma Control Test ranged from 9 to 25 (mean 20.9). The FEV1/FVC ratio fluctuated from 38 to 106 %predicted (mean, 87.4 %predicted). Associations between mold burden and asthma control differed between males and females. Thus, concentrations of some molds, particularlyAspergillus fumigatus,Aureobasidium pullulans,Stachybotrys chartarum,Alternaria alternata,Cladosporium cladosporioides 2,Cladosporium herbarum, andEpicoccum nigrum, were negatively associated with parameters of asthma control in male subjects, but not in female patients.ConclusionOur results showed that potential indoor exposure to some molds is associated with less asthma control in male subjects.