Celiac disease in a child with ulcerative colitis: a possible genetic association.
Celiac disease in a child with ulcerative colitis: a possible genetic association.
复制标题
溃疡性结肠炎儿童的乳糜泻：可能的遗传关联。
DOI：
10.1097/mcg.0b013e318250e468
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发表时间：
2013
影响因子：
2.9
通讯作者：
Pashankar,DineshS
中科院分区：
文献类型：
--
作者：
Cheng,SamX;Raizner,Aileen;Phatak,UmaP;Cho,JudyH;Pashankar,DineshS
乳糜泻和炎症性肠病，包括溃疡性结肠炎(UC)和克罗恩病，都是免疫介导的肠病。乳糜泻和炎症性肠病同时发生在单个患者身上的情况很少见。然而，这种关联在成人中已有报道，在儿童中很少发生。在这里，我们报告一个罕见的病例，一个8岁的儿童，有贫血史和不能茁壮成长，他出现血性腹泻。他的评估结果显示贫血、炎性标志物升高，以及腹腔抗体阳性。内窥镜检查显示十二指肠部分绒毛萎缩和全结肠炎。他被诊断出患有乳糜泻和UC，对无麸质饮食和类固醇/美沙拉明治疗反应良好。这位患者的基因测试显示，标记显示出对乳糜泻和UC的易感性。重要的是要意识到这种联系，因为这两种情况可以呈现出相似的临床特征，然而，需要不同的治疗方法。
Celiac disease and inflammatory bowel disease including ulcerative colitis (UC) and Crohn’s disease are both immune-mediated enteropathies. It is rare for both celiac disease and inflammatory bowel disease to occur together in an individual patient. This association has been reported in adults, however, very rarely in children. Here, we report an unusual case of an 8-year-old child with a history of anemia and failure to thrive who presented with bloody diarrhea. His evaluation showed anemia, elevated inflammatory markers, and positive celiac antibodies. Endoscopic evaluation revealed partial duodenal villous atrophy and pancolitis. He was diagnosed with celiac disease and UC and responded well to a gluten-free diet and steroid/mesalamine therapy. The patient’s genetic testing revealed markers showing susceptibility for both celiac disease and UC. It is important to be aware of this association as both conditions can present with similar clinical features, however, require different therapeutic approaches.