Sequence of the C. elegans transposable element Tc1.
Sequence of the C. elegans transposable element Tc1.
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DOI：
10.1093/nar/11.12.4201
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发表时间：
1983-06
影响因子：
14.9
通讯作者：
B. Rosenzweig;L. Liao;D. Hirsh
中科院分区：
文献类型：
--
作者：
B. Rosenzweig;L. Liao;D. Hirsh
完整的核苷酸序列确定为Tc1，在线虫秀丽隐杆线虫的转座因子。1610个碱基对的元件终止于54个碱基对的完美反向重复序列，并且侧翼是靶序列的2个碱基对的重复。Tc1序列在同一DNA链上含有两个长的开放阅读框，但在不同的翻译阅读框中。转录控制序列的位置表明，一个单一的转录本，它可以产生两个多肽，273和112个氨基酸的长度。这些特征，即末端重复、靶位点重复和开放阅读框，使得Tc1与来自其他物种的转座因子相似。
The complete nucleotide sequence was determined for Tc1, a transposable element in the nematode Caenorhabditis elegans. The 1610-base-pair element terminates in 54-base-pair perfect inverted repeats and is flanked by a 2-base-pair duplication of the target sequence. The Tc1 sequence contains two long open reading frames on the same DNA strand but in different translational reading frames. The positions of transcriptional control sequences suggest that a single transcript is made, which could produce two polypeptides, 273 and 112 amino acids in length. These features, i.e. terminal repeats, target site duplication and open reading frames, make Tc1 similar to transposable elements from other species.