Predicting relapse back to smoking: contrasting affective and physical models of dependence.
Predicting relapse back to smoking: contrasting affective and physical models of dependence.
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DOI：
10.1037/0022-006x.70.1.216
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发表时间：
2002-02
影响因子：
5.9
通讯作者：
S. Kenford;Stevens S. Smith;D. Wetter;D. Jorenby;M. Fiore;T. Baker
中科院分区：
文献类型：
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作者：
S. Kenford;Stevens S. Smith;D. Wetter;D. Jorenby;M. Fiore;T. Baker
传统的身体依赖模型表明，尼古丁依赖应该通过药物暴露的程度(例如吸烟率)和生理适应的证据(例如戒断严重程度)来反映。一个情感模型表明，尼古丁依赖应该与个人经历负面情绪的倾向和预期尼古丁使用将改善这种情绪有关。这项研究调查了这两个模型预测戒烟后6个月再次吸烟的能力。在参与尼古丁贴片临床试验的505名重度吸烟者中，建立了Logistic回归模型并进行了检验。结果支持这两个模型，但对结果最有效的预测因素是戒烟后的负面情绪，这在很大程度上解释了传统尼古丁依赖测量的预测有效性。情感反应性似乎是依赖的核心组成部分。
Traditional models of physical dependence suggest that nicotine dependence should be reflected by the extent of drug exposure (e.g., smoking rate) and by evidence of physiological adaptation (e.g., withdrawal severity). An affective model suggests that nicotine dependence should be related to an individual's tendency to experience negative affect and expectations that nicotine use would ameliorate such affect. This research investigated the ability of these 2 models to predict relapse back to smoking at 6 months postquit. Logistic regression models were developed and tested in 505 heavy smokers participating in nicotine patch clinical trials. Results supported both models, but the most potent predictor of outcome was postquit negative affect, which accounted for much of the predictive validity of traditional measures of nicotine dependence. Affective reactivity appears to be a core constituent of dependence.