Complications of growth hormone therapy in children.
Complications of growth hormone therapy in children.
复制标题
儿童生长激素治疗的并发症。
DOI：
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发表时间：
1995
影响因子：
3.6
通讯作者：
Sandra L. Blethen
中科院分区：
文献类型：
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作者：
Sandra L. Blethen
通过重组DNA技术制备的人生长激素(GH)的引入，导致接受治疗的儿童和成人数量增加。这一趋势导致了对生长激素安全性的质疑，特别是在用于生长激素缺乏以外的适应症时。本文讨论了生长激素对液体、脂肪和碳水化合物代谢的影响；颅内高压或大脑假瘤的风险；对骨骼系统的影响；恶性肿瘤的风险；以及对免疫系统的影响。目前，GH治疗似乎是安全的，尽管GH治疗患者的长期随访是必要的。
The introduction of human growth hormone (GH) prepared by recombinant DNA technology has resulted in increased numbers of children and adults receiving treatment. This trend has led to questions concerning the safety of GH, particularly when used for indications other than GH deficiency. This review discusses the effects of GH on fluid, lipid, and carbohydrate metabolism; the risk of intracranial hypertension or pseudotumor cerebri; the effects on the skeletal system; the risk of malignancy; and the effects on the immune system. At present, GH treatment appears to be safe, although long-term follow-up of GH-treated patients is necessary.