Noninvasive determination of myocardial blood flow, oxygen consumption and efficiency in normal humans by carbon-11 acetate positron emission tomography imaging
Noninvasive determination of myocardial blood flow, oxygen consumption and efficiency in normal humans by carbon-11 acetate positron emission tomography imaging
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DOI：
10.1007/s002590050480
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发表时间：
1999-11-01
期刊：
影响因子：
--
通讯作者：
Schelbert, HR
中科院分区：
文献类型：
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作者：
Porenta, G;Cherry, S;Schelbert, HR
本研究的目的是：(1)测量无创且几乎同时的心肌血流量、耗氧量和收缩功能；(2)分析正常人静息和多巴酚丁胺应激时心肌能量消耗和效率。对11名正常受试者进行动态门控碳-11醋酸酯正电子发射断层扫描（PET）成像。测定（11）c -乙酸酯的初始摄取以估计心肌血流量。耗氧量由心肌冲洗时记录的（11）c -清除率曲线的单指数斜率得出。在心肌（11）C活性峰值时获取卵泡门控收缩和舒张图像，测量左心室半径、心肌壁厚度和长轴长度。心肌耗氧量和心脏几何参数通过张力-面积-面积分析法测定心肌能量和心脏效率。静息时心肌血流量平均为0.8+/-0.06 ml min(-1) g(-1)，多巴酚丁胺应激时平均为1.48+/-0.15 ml min(-1) g（-1）。静息时供氧量为151+/-13 μ l O(2) min(-1) g(-1)，耗氧量为88+/-15 μ l O(2) min(-1) g(-1)，药物应激时分别增加到291+/-31 μ l O(2) min(-1) g（-1）
The aims of this study were: (1) to measure noninvasively and near simultaneously myocardial blood flow, oxygen consumption, and contractile function and (2) to analyze myocardial energy expenditure and efficiency at rest and during dobutamine stress in normal humans. Dynamic and gated carbon-11 acetate positron emission tomography (PET) imaging was performed in 11 normal subjects. The initial uptake of (11)C-acetate was measured to estimate myocardial blood flow. Oxygen consumption was derived from the monoexponential slope of the (11)C-clearance curve recorded during myocardial washout. EGG-gated systolic and diastolic images were acquired during the peak myocardial (11)C activity to measure left ventricular radius, myocardial wall thickness, and long axis length. Myocardial oxygen consumption and parameters of cardiac geometry were used to determine myocardial energetics and cardiac efficiency by tension-area area analysis. Myocardial blood flow averaged 0.8+/-0.06 ml min(-1) g(-1) at rest and 1.48+/-0.15 ml min(-1) g(-1) during dobutamine stress. Oxygen delivery and consumption were 151+/-13 and 88+/-15 mu l O(2) min(-1) g(-1) at rest and increased to 291+/-31 and 216+/-31 mu l O(2) min(-1) g(-1) respectively, during pharmacological stress (P