Physical activity for prevention of osteoporosis in patients with severe haemophilia on long-term prophylaxis
Physical activity for prevention of osteoporosis in patients with severe haemophilia on long-term prophylaxis
复制标题
DOI：
10.1111/j.1365-2516.2009.02186.x
复制
发表时间：
2010-05-01
期刊：
影响因子：
3.9
通讯作者：
Berntorp, E.
中科院分区：
文献类型：
--
作者：
Khawaji, M.;Astermark, J.;Berntorp, E.
体力活动被认为是骨密度的重要因素，也是促进预防骨质疏松症的因素。据报道，血友病患者的骨密度降低。研究长期预防性治疗的重度血友病患者不同方面的体力活动与骨矿物质密度（BMD）之间的关系。研究组包括38例重度血友病患者（平均年龄30.5岁）。所有患者均接受长期预防性治疗以防止出血。采用双能X线骨密度仪测量全身、腰椎、全髋、股骨颈和大转子的骨密度（BMD g cm-2）。使用自我报告的可调整活动问卷（一种收集过去12个月休闲和职业活动信息的工具）对身体活动进行评估。剧烈体力活动的持续时间（r = 0.429和P = 0.020）和强度（r = 0.430和P = 0.019）与腰椎L1-L4骨密度之间仅存在显著相关性;而体力活动的所有方面与任何其他测量部位的骨密度之间均无显著相关性。通过充分的长期预防，成人血友病患者可以保持骨量，而体力活动的强度和持续时间则起次要作用。这些结果可能支持这样一个命题，即对机械应变的反应可能是更重要的骨量发育在儿童和青少年比成人，并强调了早期发病预防的重要性。
Physical activity has been considered as an important factor for bone density and as a factor facilitating prevention of osteoporosis. Bone density has been reported to be reduced in haemophilia. To examine the relation between different aspects of physical activity and bone mineral density (BMD) in patients with severe haemophilia on long-term prophylaxis. The study group consisted of 38 patients with severe haemophilia (mean age 30.5 years). All patients received long-term prophylaxis to prevent bleeding. The bone density (BMD g cm-2) of the total body, lumbar spine, total hip, femoral neck and trochanter was measured by dual energy X-ray absorptiometry. Physical activity was assessed using the self-report Modifiable Activity Questionnaire, an instrument which collects information about leisure and occupational activities for the prior 12 months. There was only significant correlation between duration and intensity of vigorous physical activity and bone density at lumber spine L1-L4; for duration (r = 0.429 and P = 0.020) and for intensity (r = 0.430 and P = 0.019); whereas no significant correlation between all aspects of physical activity and bone density at any other measured sites. With adequate long-term prophylaxis, adult patients with haemophilia are maintaining bone mass, whereas the level of physical activity in terms of intensity and duration play a minor role. These results may support the proposition that the responsiveness to mechanical strain is probably more important for bone mass development in children and during adolescence than in adults and underscores the importance of early onset prophylaxis.