Influence of work shift on glutamic acid and gamma-aminobutyric acid (GABA): Evaluation with proton magnetic resonance spectroscopy at 3T
Influence of work shift on glutamic acid and gamma-aminobutyric acid (GABA): Evaluation with proton magnetic resonance spectroscopy at 3T
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DOI：
10.1016/j.pscychresns.2010.10.011
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发表时间：
2011-04-30
影响因子：
2.3
通讯作者：
Matsuda, Tsuyoshi
中科院分区：
文献类型：
--
作者：
Kakeda, Shingo;Korogi, Yukunori;Matsuda, Tsuyoshi
轮班工作等工作条件是失眠和白天过度嗜睡的一个众所周知的危险因素。采用3 T质子磁共振波谱（H-1-MRS）对白班和倒班工人的脑γ-氨基丁酸（GABA）、谷氨酸（Glu）、谷氨酰胺（Gln）和Glx（Glu+Gln）水平进行了比较。研究人群包括32名健康成年志愿者（16名白班工人和16名轮班工人）。每例受试者在同一天清晨和傍晚接受使用MEGA-PRESS序列进行的MRS。将光谱体素（3.0 cm x 3.0 cm x 3.0 cm）置于额叶和顶枕叶。在傍晚时分，交替轮班组额叶的GABA/Cr比值显著低于白班组（1.885 vs. 0.875）。对于其他代谢物比值（Gln/Cr和Glx/Cr），无论早晨或晚上的时间表，两组之间均无显著差异。我们的初步发现表明，大脑中GABA含量可能会发生变化，这与不规律的工作时间表有关。(C)2010爱思唯尔爱尔兰有限公司版权所有。
Working conditions such as shift work constitute a well-known risk factor for insomnia and excessive daytime sleepiness complaints. We compared brain gamma-aminobutyric acid (GABA), glutamic acid (Glu), glutamine (Gin), and Glx (Glu+Gln) levels in day-shift versus alternate-shift workers with proton magnetic resonance spectroscopy (H-1-MRS) at 3T. The study population consisted of 32 healthy adult volunteers (16 day-shift and 16 alternate-shift workers). Each subject underwent MRS conducted using a MEGA-PRESS sequence in the early morning and early evening on the same day. Spectroscopy voxels (3.0 cm x 3.0 cm x 3.0 cm) were placed in the frontal lobe and parieto-occipital lobe. The GABA/Cr ratio in the frontal lobe was significantly lower for the alternate-shift group than for the day-shift group in the early evening (1.885 vs. 0.875). For the other metabolite ratios (Gln/Cr and Glx/Cr), there were no significant differences between the two groups regardless of morning or evening schedule. Our preliminary finding represents a possible alteration of GABA content in the brain related to an irregular work schedule. (C) 2010 Elsevier Ireland Ltd. All rights reserved.