Leaving Group Ability in Nucleophilic Aromatic Amination by Sodium Hydride-Lithium Iodide Composite

Leaving Group Ability in Nucleophilic Aromatic Amination by Sodium Hydride-Lithium Iodide Composite
复制标题

氢化钠-碘化锂复合材料亲核芳香胺化的离去基团能力

DOI：
10.1055/s-0039-1690010
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发表时间：
2019
期刊：
Synthesis
影响因子：
--
通讯作者：
Chiba Shunsuke
Chiba Shunsuke
中科院分区：
--
文献类型：
--
作者：
Pang Jia Hao;Ong Derek Yiren;Watanabe Kohei;Takita Ryo;Chiba Shunsuke

文献摘要

相似文献

甲氧基通常被认为是亲核取代反应的不良离开基团。本工作通过实验和计算验证了甲氧基在氢化钠和碘化锂催化的芳烃亲核胺化反应中的优越能力。
The methoxy group is generally considered as a poor leaving group for nucleophilic substitution reactions. This work verified the superior ability of the methoxy group in nucleophilic amination of arenes mediated by the sodium hydride and lithium iodide through experimental and computational approaches.