Preparation of drug nanoparticles by emulsion evaporation method
Preparation of drug nanoparticles by emulsion evaporation method
复制标题
乳化蒸发法制备药物纳米粒
DOI：
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
D. M. Chien
中科院分区：
文献类型：
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作者：
L. M. Hoa;N. T. Chi;N. M. Triet;L. Nhan;D. M. Chien
采用乳化溶剂蒸发法制备高分子药物纳米粒。本研究制备了由酮洛芬和Eudragit E 100组成的聚合物药物纳米颗粒，并通过扫描电子显微镜（SEM）研究了其形貌结构。通过傅里叶变换红外光谱（FTIR）研究了药物和聚合物之间的相互作用。通过动态光散射测量尺寸分布。纳米颗粒的平均尺寸约为150 nm。药物在聚合物纳米粒子中的掺入能力取决于聚合物和药物之间的结合以及聚合物的玻璃化转变温度。
Polymeric drug nanoparticles were prepared by emulsion solvent evaporation method. In this study, prepared the polymeric drug nanoparticles consist of ketoprofen and Eudragit E 100. The morphology structure was investigated by scanning electron microscopy (SEM). The interactions between the drug and polymer were investigated by Fourier transform infrared spectroscopy (FTIR). The size distribution was measured by means of Dynamic Light Scattering. The nanoparticles have an average size of about 150 nm. The incorporation ability of drugs in the polymeric nanoparticles depended on the integration between polymer and drug as well as the glass transition temperature of the polymer.