DIABETIC CARDIOMYOPATHY IN RATS - MECHANICAL AND BIOCHEMICAL RESPONSE TO DIFFERENT INSULIN DOSES
DIABETIC CARDIOMYOPATHY IN RATS - MECHANICAL AND BIOCHEMICAL RESPONSE TO DIFFERENT INSULIN DOSES
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DOI：
10.1152/ajpheart.1984.247.5.h817
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发表时间：
1984-01-01
影响因子：
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通讯作者：
SONNENBLICK, EH
中科院分区：
文献类型：
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作者：
FEIN, FS;MALHOTRA, A;SONNENBLICK, EH
糖尿病会导致人类充血性心力衰竭，与动脉粥样硬化无关。本研究扩展了先前关于胰岛素对糖尿病大鼠观察到的心肌功能和收缩蛋白生物化学变化的可逆性的研究。探索了这些改变对不同固定剂量胰岛素的反应。糖尿病大鼠每天给予 0、0.5、1、1.5、2 或 2.5 U 胰岛素，持续 6 周。随着血糖浓度恢复正常，随着胰岛素剂量的增加，乳头肌功能、肌动球蛋白 ATP 酶和肌球蛋白同工酶分布逐渐正常化。当糖尿病大鼠接近正常血糖时，正常饮食的胰岛素治疗可不断改善心脏功能和生物化学。与在严重糖尿病大鼠中观察到的结果相比，轻度糖尿病导致的心肌变化在质量上是相同的，尽管在数量上不太明显。
Diabetes mellitus causes congestive heart failure in humans, independent of atherosclerosis. The present study extends previous work on the reversibility, with insulin, of the alterations in myocardical function and contractile protein biochemistry observed in diabetic rats. The response of these alterations to different fixed doses of insulin was explored. Diabetic rats were given 0, 0.5, 1, 1.5, 2 or 2.5 U of insulin daily for 6 wk. Papillary muscle function, actomyosin ATPase, and myosin isoenzyme distribution showed progressive normalization with increasing insulin dose as blood glucose concentration returned to normal. Insulin therapy in diabetic rats on a normal diet produces continuous improvement in cardiac function and biochemistry as euglycemia is approached. Mild diabetes results in qualitatively identical, although quantitatively less pronounced, myocardial changes compared with those observed in severely diabetic rats.