Birth Weight, Stress, and Symptoms of Depression in Adolescence: Evidence of Fetal Programming in a National Canadian Cohort
Birth Weight, Stress, and Symptoms of Depression in Adolescence: Evidence of Fetal Programming in a National Canadian Cohort
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DOI：
10.1177/070674371205700705
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发表时间：
2012-07-01
影响因子：
4
通讯作者：
Van Lieshout, Ryan J.
中科院分区：
文献类型：
--
作者：
Colman, Ian;Ataullahjan, Anushka;Van Lieshout, Ryan J.
目的：通过研究出生体重高或低的青少年在经历压力后是否更有可能出现抑郁和焦虑症状，来探究人类胎儿编程的证据。
方法：样本包括加拿大一项前瞻性队列研究的3732名成员，他们在12至15岁（2006/2007年）时接受了抑郁和焦虑症状评估，并且在1994/1995年记录了出生体重和胎龄数据。整个童年时期还报告了重大的生活压力事件和慢性压力源。
结果：在对急性和慢性压力进行调整后，与胎龄相符体重出生的青少年相比，小于胎龄儿（SGA）（比值比1.50；95%置信区间1.08 - 2.08）或大于胎龄出生（比值比1.31；95%置信区间0.99 - 1.72）与青少年时期抑郁和焦虑风险增加有关。出生体重和压力之间的大多数相互作用并不显著；然而，在小于胎龄出生的男性中，慢性压力与青少年抑郁和焦虑之间的关系更为明显（相互作用P < 0.05）。
结论：出生体重与抑郁之间的联系是复杂的，胎儿编程的证据并不一致；然而，出生体重低的人在面临慢性压力时可能抑郁风险增加。
Objective: To investigate evidence of fetal programming in humans by studying whether adolescents born at high or low birth weights (LBW) are more likely to experience symptoms of depression and anxiety after experiencing stress.Method: The sample included 3732 members of a prospective Canadian cohort study assessed for symptoms of depression and anxiety at age 12 to 15 years (2006/2007), and had birth weight and gestational age (GA) data recorded in 1994/1995. Major stressful life events and chronic stressors were also reported throughout childhood.Results: After adjusting for acute and chronic stress, being born small for GA (SGA) (OR 1.50; 95% CI 1.08 to 2.08) or large (OR 1.31; 95% CI 0.99 to 1.72) for GA was associated with an increased risk of depression and anxiety in adolescence, compared with adolescents who were born at a weight appropriate for their GA. Most interactions between birth weight and stress were not significant; however, the relation between chronic stress and adolescent depression and anxiety was more pronounced in males who were born SGA (interaction P < 0.05).Conclusions: The link between birth weight and depression is complex and evidence of fetal programming is inconsistent; however, people born at LBW may be at an increased risk of depression in the face of chronic stress.