Variations in the core promoter/pre-core region in HBV genotype C in Japanese and northern Vietnamese patients
Variations in the core promoter/pre-core region in HBV genotype C in Japanese and northern Vietnamese patients
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DOI：
10.1002/jmv.20934
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发表时间：
2007-09-01
影响因子：
12.7
通讯作者：
Kasuga, Masato
中科院分区：
文献类型：
--
作者：
Truong, Bui Xuan;Yano, Yoshihiko;Kasuga, Masato
Hepatitis B virus (HBV) subgenotypes Cs (CII) and Ce (C2) are common in East Asia. To investigate the genomic difference of HBV genotype C between two separated regions, 50 subgenotype Cs-infected Vietnamese and 70 subgenotype Ce-infected Japanese patients were enrolled for analysis. The patients were categorized to either a hepatocellular carcinoma group (HCC) or a non-HCC group including liver cirrhosis, chronic hepatitis, and asymptornatic carriers. HBV serology, HBV-DNA level, and variations in core promoter/pre-core region were examined. Phylogenetic analysis based on the full genome sequences and nucleoticle sequences partly in the S gene and in the P gene revealed that all Japanese strains (70/70) were subgenotype Ce, and nearly all of the Vietnamese strains (50/51) were subgenotype Cs, excluding one subgenotype C5. C1858 and G1775 were common in the Vietnamese (64% and 40%) but not in the Japanese (0%). The prevalence of C/A1753 in Vietnamese was higher than that in the Japanese (32% vs. 17.1%), however the frequency of A1896 in the Japanese was significantly higher (32.9% vs. 12%, P
