AMPLITUDE-MODULATION OF A BURSTLIKE MODE OF CORTISOL SECRETION SUBSERVES THE CIRCADIAN GLUCOCORTICOID RHYTHM
AMPLITUDE-MODULATION OF A BURSTLIKE MODE OF CORTISOL SECRETION SUBSERVES THE CIRCADIAN GLUCOCORTICOID RHYTHM
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DOI：
10.1152/ajpendo.1989.257.1.e6
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发表时间：
1989-07-01
影响因子：
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通讯作者：
JOHNSON, ML
中科院分区：
文献类型：
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作者：
VELDHUIS, JD;IRANMANESH, A;JOHNSON, ML
我们已经研究了机制subserving在体内的昼夜节律的皮质醇在男性。为此，血液样本抽取在10分钟的时间间隔为24小时，在每个六名男子产生明确的配置文件的发作性皮质醇释放。一种新的多参数去卷积模型被应用于歧视的数量，幅度和持续时间的所有统计学显着的潜在的皮质醇分泌爆发的血浆激素浓度，同时估计内源性半衰期的皮质醇消失在每个主题。这些实验揭示了随机发生的皮质醇分泌爆发，平均频率为每天19 ± 0.82次（脉冲间隔77 ± 4.0分钟）。分泌爆发的平均半持续时间（半最大振幅时的持续时间）仅为16 ± 0.61 min，表明95%的每日皮质醇分泌发生在8.2 h内。皮质醇分泌爆发频率变化2.2倍，而皮质醇分泌爆发幅度变化6.6倍。我们的结论是，在体内的皮质醇变化的昼夜模式可以解释由一个振幅调制，随机突发式的皮质醇分泌模式，而不需要假设一个紧张的皮质醇释放模式。
We have examined the mechanism subserving the in vivo circadian rhythm of cortisol in men. To this end, blood samples were withdrawn at 10-min intervals for 24 h in each of six men to yield well-defined profiles of episodic cortisol release. A novel multiple-parameter deconvolution model was applied to discriminate the number, amplitudes, and durations of all statistically significant underlying cortisol secretory bursts from the plasma hormone concentrations and simultaneously estimate the endogenous half-life of cortisol disappearance in each subject. These experiments disclosed randomly occurring cortisol secretory bursts at a mean frequency of 19 +/- 0.82 events per day (interpulse interval 77 +/- 4.0 min). Secretory bursts exhibited a mean half-duration (duration at half-maximal amplitude) of only 16 +/- 0.61 min indicating that 95% of daily cortisol secretion occurred in 8.2 h. Cortisol secretory burst frequency varied 2.2-fold over 24 h, whereas cortisol secretory burst amplitude varied 6.6-fold. We conclude that the nyctohemeral pattern of cortisol variation in vivo can be accounted for by an amplitude-modulated, random burstlike mode of cortisol secretion without the need to postulate a tonic mode of cortisol release.