Involvement of TNF in limiting liver pathology and promoting parasite survival during schistosome infection
Involvement of TNF in limiting liver pathology and promoting parasite survival during schistosome infection
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DOI：
10.1016/j.ijpara.2003.10.010
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发表时间：
2004-01-01
影响因子：
4
通讯作者：
McKerrow, JH
中科院分区：
文献类型：
--
作者：
Davies, SJ;Lim, KC;McKerrow, JH
CD4（+）T细胞反应和巨噬细胞活化是虫卵诱导的肉芽肿形成的重要组成部分。以前的研究表明，肿瘤坏死因子（TNF）作为一个潜在的介导的巨噬细胞的招聘和激活在巨噬细胞感染。在这里，我们表明，信号通过TNF及其受体可以影响肉芽肿的形成，但最终在这个系统中肉芽肿的形成。然而，我们确定了一个以前未认识到的作用，TNF在限制肝细胞损伤的反应，以卵母细胞。此外，我们表明，这种活性的TNF是独立的TNF受体（TNFR1和TNFR2）。总之，这些数据表明，额外的，尚未识别的受体存在的TNF和这些受体能够介导重要的病理作用在肝脏中。最后，我们提供的证据表明，TNF发挥了意想不到的作用，在维持成年人肝小体的活力在门静脉系统。(C)2003年代表澳大利亚寄生虫学会由爱思唯尔有限公司出版。保留所有权利。
CD4(+) T cell responses and macrophage activation are essential components of schistosome egg-induced granuloma formation. Previous studies implicated tumour necrosis factor (TNF) as a potential mediator of macrophage recruitment and activation during schistosome infection. Here we demonstrate that signalling by TNF and its receptors can influence granuloma formation, but is ultimately dispensable for granuloma formation in this system. However, we identify a previously unrecognised role for TNF in limiting hepatocellular damage in response to schistosome eggs. Further, we show that this activity of TNF is independent of TNF receptors (TNFR1 and TNFR2). Taken together, these data suggest that additional, as yet unrecognised receptors exist for TNF and that these receptors are capable of mediating important pathological effects in the liver. Finally, we provide evidence that TNF plays an unexpected role in maintaining adult schistosome viability in the portal system. (C) 2003 on behalf of Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.