Reduced postpartum hippocampal volume is associated with positive mother-infant caregiving behavior.
Reduced postpartum hippocampal volume is associated with positive mother-infant caregiving behavior.
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DOI：
10.1016/j.jad.2020.12.014
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发表时间：
2021-02-15
影响因子：
6.6
通讯作者：
Hipwell AE
中科院分区：
文献类型：
--
作者：
Moses-Kolko EL;Banihashemi L;Hipwell AE
母亲分娩是一组复杂的行为，可能会受到早期生活压力（ELS）的影响，但人类的神经生物学机制尚未得到很好的理解。年轻母亲（n=137）被纳入纵向匹兹堡女孩研究（PGS）的神经影像学子研究。使用受试者8-16岁时每年收集的数据，ELS计算为贫困、创伤和困难生活环境的综合评分。在产后4个月，母亲接受神经成像和拍摄母婴互动。母亲的生育行为被编码为沿着6个维度，产生“积极”和“消极”的组成部分的生育行为。参与者的MPPT图像经过预处理和基于体素的形态测量（VBM），以量化vmPFC，杏仁核和海马灰质（GM）体积。我们使用分层线性回归来研究GM体积与母亲分娩、ELS协变以及母亲年龄、产后周数、种族和产后抑郁评分之间的关系。海马GM体积与阳性母体妊娠的独立观察结果呈负相关。在多重比较校正后，vmPFC中的类似结果并不显著。ELS，特别是身体攻击，与GM数量的减少有关，但与观察到的孕产妇死亡无关。我们的单时间点MRI为基础的GM体积方法是不能证明时间相关的个体内围产期神经可塑性，也不能解决神经亚区参与发育相关的可塑性。我们的研究结果揭示了人类母体下丘脑外应激回路潜在的可塑性。海马GM体积减少是否代表修剪或代表面对ELS的神经弹性，仍有待研究。
Maternal caregiving is a complex set of behaviors that can be impacted by early life stress (ELS), yet human neurobiological mechanisms are not well understood. Young mothers (n=137) were enrolled into a neuroimaging substudy of the longitudinal Pittsburgh Girls Study (PGS). Using data collected annually while subjects were ages 8–16, ELS was calculated as a composite score of poverty, trauma, and difficult life circumstances. At 4 months postpartum, mothers underwent neuroimaging and filmed mother-infant interaction. Maternal caregiving was coded along 6 dimensions yielding “positive” and “negative” components of caregiving. Participants’ MPRAGE images were subjected to preprocessing and voxel-based morphometry (VBM) to quantify vmPFC, amygdala and hippocampus gray matter (GM) volume. We used hierarchical linear regression to investigate the relationship between GM volume and maternal caregiving, covarying for ELS as well as maternal age, weeks postpartum, race and postpartum depression score. Hippocampal GM volume was inversely associated with independent observations of positive maternal caregiving. Similar findings in the vmPFC did not remain significant after correction for multiple comparisons. ELS, particularly physical assault, was associated with reduced GM volumes but was unrelatedto observed maternal caregiving. Our single-timepoint MRI-based GM volume method was not able to demonstrate time-related intra-individual perinatal neuroplasticity, nor could it resolve neural subregions involved in caregiving-related plasticity. Our findings shed light on the putative plasticity of the human maternal extra-hypothalamic stress-circuitry underlying positive maternal caregiving behavior. Whether reduced hippocampal GM volume represents pruning or represents neural resilience in the face of ELS, remains to be studied.
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影响因子：
3.8
作者：
Leventhal, A;Jacobsen, T;Quintana, E
通讯作者：
Quintana, E
DOI：
10.1080/15374416.2010.486320
发表时间：
2010
期刊：
Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
影响因子：
--
作者：
Keenan K;Hipwell A;Chung T;Stepp S;Stouthamer-Loeber M;Loeber R;McTigue K
通讯作者：
McTigue K
影响因子：
3.2
作者：
Moses-Kolko EL;Horner MS;Phillips ML;Hipwell AE;Swain JE
通讯作者：
Swain JE
影响因子：
10.6
作者：
Heim, C;Nemeroff, CB
通讯作者：
Nemeroff, CB
影响因子：
4.8
作者：
Cooke, Jessica E.;Racine, Nicole;Madigan, Sheri
通讯作者：
Madigan, Sheri