A facile one-step in situ functionalization of quantum dots with preserved photoluminescence for bioconjugation
A facile one-step in situ functionalization of quantum dots with preserved photoluminescence for bioconjugation
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一种简单的一步原位量子点功能化，保留光致发光用于生物共轭
DOI：
10.1021/ja071434y
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发表时间：
2007-05-23
影响因子：
15
通讯作者：
Yan, Hao
中科院分区：
文献类型：
--
作者：
Wang, Qiangbin;Xu, Yang;Yan, Hao
在此，我们报告了一种新的简单方法，可以同时通过薄 ZnS 壳对 CdSe QD 进行原位功能化和表面钝化。该方法避免了核壳形成后的第二步配体交换，并保持了量子点的高量子产率。我们证明了这种制备的量子点可以作为优异的生物共轭纳米材料。不同的抗体与 MPA 功能化的量子点缀合，产生高度稳定和高度光致发光的纳米颗粒，用于细胞标记目的。
Herein we report a new and simple method of in situ functionalization of CdSe QDs and surface passivation by a thin ZnS shell at the same time. This method avoids a second-step ligand exchange after the core-shell formation and preserved high quantum yield of the QDs. We demonstrated that such prepared QDs can serve as excellent nanomaterial for bioconjugation. Different antibodies were conjugated to the MPA-functionalized QDs and resulted in highly stable and highly photoluminescent nanoparticles for cell labeling purposes.