The endocrine response to ghrelin as a function of gender in humans in young and elderly subjects
The endocrine response to ghrelin as a function of gender in humans in young and elderly subjects
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DOI：
10.1210/jc.2002-021504
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发表时间：
2003-04-01
影响因子：
5.8
通讯作者：
Ghigo, E
中科院分区：
文献类型：
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作者：
Broglio, F;Benso, A;Ghigo, E
Ghrelin调节促生长素、促乳素、促皮质素、胰岛素分泌和葡萄糖代谢。为了阐明性别和年龄对生长素释放肽内分泌作用的影响，我们研究了生长素释放肽（1.0 μ g/kg iv）或安慰剂对18名年轻受试者（YS）和16名老年受试者（ES）的GH、催乳素（PRL）、ACTH、皮质醇、胰岛素、胰高血糖素和葡萄糖水平的影响。还研究了GH对GHRH（1.0 μ g/kg iv）的反应。YS组GH对Ghrelin的反应高于ES组（P < 0.01），两者均高于GHRH（P < 0.01），无性别差异。在YS中，ghrelin还诱导：1）PRL、ACTH和皮质醇水平的性别非依赖性增加（P < 0.01）; 2）葡萄糖水平的性别非依赖性增加（P < 0.01）; 3）男性YS中胰岛素水平的降低（P < 0.01）;以及4）胰高血糖素没有变化。在ES中，ghrelin诱导了与性别无关的PRL、ACTH和皮质醇反应（P < 0.01）。在ES中，ghrelin引起非性别依赖性的胰岛素一过性降低（P < 0.01），同时伴有葡萄糖水平升高（P < 0.05）。总之，生长激素释放肽的生长激素释放作用是独立的性别，但经历年龄相关的减少。生长激素释放肽对促乳素和促肾上腺皮质激素分泌的影响与年龄和性别无关。在ES和YS中，ghrelin影响胰岛素分泌和葡萄糖代谢。
Ghrelin modulates somatotroph, lactotroph, corticotroph, and insulin secretion and glucose metabolism. To clarify the influence of gender and age on the endocrine actions of ghrelin in humans, we studied the effects of ghrelin (1.0 mug/kg iv) or placebo on GH, prolactin (PRL), ACTH, cortisol, insulin, glucagon, and glucose levels in 18 young subjects (YS) and 16 elderly subjects (ES) of both genders. The GH response to GHRH (1.0 mug/kg iv) was also studied. The GH response to ghrelin in YS was higher (P < 0.01) than in ES and both higher (P < 0.01) than to GHRH, without gender-related differences. In YS ghrelin also induced: 1) gender-independent increase (P < 0.01) in PRL, ACTH, and cortisol levels; 2) gender-independent increase in glucose levels (P < 0.01); 3) decrease (P < 0.01) in insulin levels in male YS; and 4) no change in glucagon. In ES, ghrelin induced gender-independent PRL, ACTH, and cortisol responses (P < 0.01). In ES ghrelin elicited gender-independent transient decrease in insulin (P < 0.01) coupled with increase in glucose levels (P < 0.05). In conclusion, the GH-releasing effect of ghrelin is independent of gender but undergoes age-related decrease. The effect of ghrelin on lactotroph and corticotroph secretion is age and gender independent. In both ES and YS, ghrelin influences insulin secretion and glucose metabolism.