Early-Onset Parkinsonism and Early-Onset Parkinson's Disease: A Population-Based Study (2010-2015).
Early-Onset Parkinsonism and Early-Onset Parkinson's Disease: A Population-Based Study (2010-2015).
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DOI：
10.3233/jpd-202464
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Savica R
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文献类型：
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作者：
Camerucci E;Stang CD;Hajeb M;Turcano P;Mullan AF;Martin P;Ross OA;Bower JH;Mielke MM;Savica R
早发性帕金森病（EOPD）发生在40至55岁之间，具有社会，社会和个人后果，并且可能进展，与典型的迟发性疾病相比，合并症较少。研究明尼苏达州7个县55岁以前发生的EOPD和其他帕金森综合征的发病率和生存率。一位运动障碍专家回顾了2010-2015年帕金森病事件队列的所有医疗记录，以确认诊断和亚型。2010-15年，我们确定了27例在<50岁时诊断为偶发帕金森症的患者：11例（41%）EOPD，13例（48%）药物诱导的帕金森症，3例（11%）其他帕金森症，69例<55岁的帕金森症偶发病例。<50岁帕金森综合征的总发病率为1.98/100，000人-年，EOPD为0.81/100，000人-年。在<55岁的患者中，帕金森综合征的发病率为5.05/100，000人-年;在EOPD中，为2.05/100，000人-年。45%的EOPD患者（<50岁和<55岁）存在左旋多巴诱导的运动障碍。主要运动症状的发作与EOPD的诊断接近，但姿势反射受损除外，后者发生在EOPD的后期。在69例<55岁的帕金森病患者中，9例（13%;均为男性）死亡（仅1例EOPD）。男性的死亡风险高于女性（p= 0.049）。<50岁的EOPD发病率为0.81/100，000人-年（所有类型的帕金森病为1.98）; 55岁之前为2.05/100，000人-年（所有类型的帕金森病为5.05），男性发病率高于女性。所有类型的帕金森症男性患者的死亡率均高于女性。
Early-onset Parkinson’s disease (EOPD), occurring between ages 40 and 55, carries social, societal, and personal consequences and may progress, with fewer comorbidities than typical, later-onset disease. To examine the incidence and survival of EOPD and other Parkinsonism occurring before age 55 in the population-based cohort of residents in seven Minnesota counties. A movement-disorder specialist reviewed all the medical records in a 2010–2015 Parkinsonism-incident cohort to confirm diagnosis and subtypes. We identified 27 patients diagnosed at <50 years with incident Parkinsonism 2010–15: 11 (41%) cases of EOPD, 13 (48%) drug-induced Parkinsonism, and 3 (11%) other Parkinsonism and 69 incident cases of Parkinsonism <55 years of age. Overall incidence for Parkinsonism <50 years was 1.98/100,000 person-years, and for EOPD was 0.81/100,000 person-years. In patients <55 years, Parkinsonism incidence was 5.05/100,000 person-years: in EOPD, 2.05/100,000 person-years. Levodopa-induced dyskinesia was present in 45% of EOPD (both <50 years and <55 years). Onset of cardinal motor symptoms was proximate to the diagnosis of EOPD, except for impaired postural reflexes, which occurred later in the course of EOPD. Among the 69 Parkinsonism cases <55 years, 9 (13%; all male) were deceased (only 1 case of EOPD). Men had a higher mortality risk compared to women (p= 0.049). The incidence of EOPD <50 years was 0.81/100,000 person-years (1.98 in Parkinsonism all type); prior to 55 years was 2.05/100,000 person-years (5.05 in Parkinsonism all type) with higher incidence in men than women. Men with Parkinsonism, all type, had higher mortality compared to women.