Differences in Liver Parenchyma are Measurable with CT Radiomics at Initial Colon Resection in Patients that Develop Hepatic Metastases from Stage II/III Colon Cancer.
Differences in Liver Parenchyma are Measurable with CT Radiomics at Initial Colon Resection in Patients that Develop Hepatic Metastases from Stage II/III Colon Cancer.
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DOI：
10.1245/s10434-020-09134-w
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发表时间：
2021-04
影响因子：
3.7
通讯作者：
Simpson AL
中科院分区：
文献类型：
--
作者：
Creasy JM;Cunanan KM;Chakraborty J;McAuliffe JC;Chou J;Gonen M;Kingham VS;Weiser MR;Balachandran VP;Drebin JA;Kingham TP;Jarnagin WR;D'Angelica MI;Do RKG;Simpson AL
目前，还没有方法来识别肝转移风险增加的患者，以指导患者选择肝靶向治疗。我们试图确定在初始结肠切除术时从术前分期CT扫描获得的肝脏定量图像特征（放射组学）是否与随后发生肝转移、肝外转移或无病生存期延长的患者不同。这项单机构、回顾性病例对照研究纳入了2004-2012年接受II/III期结肠癌切除术且术前CT扫描可用的患者。患者按初始复发模式分组：肝脏复发、肝外复发或5年时无疾病证据。从CT图像中提取的肝实质的放射组学特征进行了比较。该队列由120名患者组成，平均分为三个复发组，每组中II期和III期患者数量相等。在调整多重比较后，254个影像学特征中的44个（17%）在三个患者组中显示出不同的分布（p < 0.05），其中肝脏复发和无疾病证据之间的差异最明显。通过放射组学分析，肝实质异质性增加对肝转移具有保护作用。CT放射组学是一种很有前途的工具，以确定患者在高风险的发展肝转移，值得进一步研究和验证。
Currently, there are no methods to identify patients with an increased risk of liver metastases to guide patient selection for liver-directed therapies. We tried to determine whether quantitative image features (radiomics) of the liver obtained from preoperative staging CT scans at the time of initial colon resection differ in patients that subsequently develop liver metastases, extrahepatic metastases, or demonstrate prolonged disease-free survival. Patients who underwent resection of stage II/III colon cancer from 2004–2012 with available preoperative CT scans were included in this single-institution, retrospective case-control study. Patients were grouped by initial recurrence patterns: liver recurrence, extrahepatic recurrence, or no evidence of disease at 5 years. Radiomic features of the liver parenchyma extracted from CT images were compared across groups. The cohort consisted of 120 patients divided evenly between three recurrence groups, with an equal number of stage II and III patients in each group. After adjusting for multiple comparisons, 44 of 254 (17%) imaging features displayed different distributions across the three patient groups (p < 0.05), with the clearest distinction between those with liver recurrence and no evidence of disease. Increased heterogeneity in the liver parenchyma by radiomic analysis was protective of liver metastases. CT radiomics is a promising tool to identify patients at high risk of developing liver metastases and is worthy of further investigation and validation.
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影响因子：
6.2
作者：
Casadaban, Leigh;Rauscher, Garth;Aklilu, Mebea;Villenes, Dana;Freels, Sally;Maker, Ajay V.
通讯作者：
Maker, Ajay V.
影响因子：
2.9
作者：
Tan, Marcus C. B.;Butte, Jean M.;D'Angelica, Michael I.
通讯作者：
D'Angelica, Michael I.
影响因子：
8
作者：
Buczkowski, S;Kyriacos, S;Cartilier, L
通讯作者：
Cartilier, L
影响因子：
1.1
作者：
Chakraborty, Jayasree;Rangayyan, Rangaraj M.;Desautels, J. E. Leo
通讯作者：
Desautels, J. E. Leo
影响因子：
3.3
作者：
Ganeshan, Balaji;Miles, Kenneth A.;Chatwin, Chris R.
通讯作者：
Chatwin, Chris R.