Are brominated flame retardants endocrine disruptors?
Are brominated flame retardants endocrine disruptors?
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DOI：
10.1016/s0160-4120(03)00104-1
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发表时间：
2003-09-01
影响因子：
11.8
通讯作者：
Brouwer, A
中科院分区：
文献类型：
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作者：
Legler, J;Brouwer, A
溴化阻燃剂（BFRs）是一类最近受到广泛关注的化合物，因为它们在命运、环境稳定性以及在人类和野生动物中的积累方面与“老”类有机卤化化合物（如多氯联苯（PCBs））相似。已观察到一些BFR同系物的毒性作用，包括致畸性、致癌性和神经毒性，特别是溴化二苯醚（BDEs）。这篇简明的综述着重于BFRs的效力和对内分泌系统的干扰，并试图回答BFRs是否是内分泌干扰物的问题。提供了关于溴化阻燃剂对甲状腺激素系统的破坏的证据，特别强调溴化阻燃剂，因为这类阻燃剂的最新数据是可用的。与羟基化多氯联苯类似，体外机制研究和动物实验都证明了BDEs对甲状腺激素转运和代谢的影响。本文还概述了BFRs对雌激素系统可能产生的影响。概述了研究差距，以及欧洲共同体正在进行的和未来的研究，旨在促进基于生物燃料排放物干扰内分泌影响的全面风险评估。2003爱思唯尔科学有限公司版权所有。
Brominated flame retardants (BFRs) are a group of compounds that have received much attention recently due to their similarity with "old" classes of organohalogenated compounds such as polychlorinated biphenyls (PCBs), in terms of their fate, stability in the environment and accumulation in humans and wildlife. Toxic effects, including teratogenicity, carcinogenicity and neurotoxicity, have been observed for some BFR congeners, in particular the brominated diphenyl ethers (BDEs). This concise review focuses on the potency of BFRs and to disrupt endocrine systems, and attempts to answer the question whether or not BFRs are endocrine disruptors. Evidence is provided on the disruption of the thyroid hormone system by BFRs, with particular emphasis on the BDEs, as most recent data is available on this class of flame retardants. Similar to the hydroxylated PCBs, in vitro mechanistic studies as well as animal experiments have demonstrated the effects of BDEs on thyroid hormone transport and metabolism. An overview of possible effects of BFRs on the estrogen system is also provided. Research gaps are outlined, as well as ongoing and future studies in the European community aimed at contributing to comprehensive risk assessments based on the endocrine-disrupting effects of BFRs. (C) 2003 Elsevier Science Ltd. All rights reserved.