A neuropeptidergic circuit gates selective escape behavior of Drosophila larvae
A neuropeptidergic circuit gates selective escape behavior of Drosophila larvae
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DOI：
10.1016/j.cub.2021.10.069
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发表时间：
2022-01-10
期刊：
影响因子：
9.2
通讯作者：
Soba, Peter
中科院分区：
文献类型：
--
作者：
Imambocus, Bibi Nusreen;Zhou, Fangmin;Soba, Peter
动物在面对环境威胁时会表现出选择性的逃避行为。通过底层神经元网络选择适当的反应是最大化生存机会的关键，但底层网络机制迄今尚未完全理解。通过对果蝇幼虫网络进行突触水平重建，并结合生理和行为读数，我们发现了一种通过急性和输入特异性神经肽作用来控制有害光选择性逃逸行为的电路。感觉神经元需要避免有害的光和逃避响应于苛刻的触摸，每个收敛于神经调节中枢神经元的离散域。我们发现，急性释放中枢神经元衍生的胰岛素样肽7（ILP7）和下游神经元中的同源松弛素家族受体（LGR 4）信号传导是避免有害光所必需的，但不是苛刻的触摸反应。我们的工作突出了分隔电路组织和神经肽从监管枢纽释放的作用，作为中央电路元件门控逃避反应。
Animals display selective escape behaviors when faced with environmental threats. Selection of the appropriate response by the underlying neuronal network is key to maximizing chances of survival, yet the underlying network mechanisms are so far not fully understood. Using synapse-level reconstruction of the Drosophila larval network paired with physiological and behavioral readouts, we uncovered a circuit that gates selective escape behavior for noxious light through acute and input-specific neuropeptide action. Sensory neurons required for avoidance of noxious light and escape in response to harsh touch, each converge on discrete domains of neuromodulatory hub neurons. We show that acute release of hub neuron-derived insulin-like peptide 7 (Ilp7) and cognate relaxin family receptor (Lgr4) signaling in downstream neurons are required for noxious light avoidance, but not harsh touch responses. Our work highlights a role for compartmentalized circuit organization and neuropeptide release from regulatory hubs, acting as central circuit elements gating escape responses.