Benzodiazepine, psychotropic medication, and dementia: A population-based cohort study
Benzodiazepine, psychotropic medication, and dementia: A population-based cohort study
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DOI：
10.1016/j.jalz.2015.10.006
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发表时间：
2016-05-01
影响因子：
14
通讯作者：
Tzourio, Christophe
中科院分区：
文献类型：
--
作者：
Shash, Dalia;Kurth, Tobias;Tzourio, Christophe
苯二氮卓类药物的使用与痴呆风险增加有关。然而，目前尚不清楚这种风险是否与半衰期较短或较长的苯二氮卓类药物有关，以及它是否延伸到其他精神药物。方法：对8240名bb0 = 65的患者进行前瞻性队列研究。经过多步骤治疗后，终点委员会确认了偶发性痴呆。结果：在平均8年的随访中，共观察到830例痴呆病例。基线时使用苯二氮卓类药物的患者患痴呆的风险增加10%（调整后的风险比[HR]为1.10；95%可信区间为0.90-1.34）。然而，与半衰期短的使用者（HR = 1.05; 0.85-1.30）相比，半衰期长的苯二氮卓类药物使用者患痴呆的风险明显增加（HR = 1.62; 1.11-2.37）。精神类药物的使用者患痴呆的风险增加（HR = 1.47; 1.16-1.86）。讨论：这项大型前瞻性研究的结果显示，半衰期较长的苯二氮卓类药物和精神药物的使用增加了痴呆的风险。(C) 2015年阿尔茨海默病协会。Elsevier Inc.出版。版权所有。
Introduction: Benzodiazepine use has been associated with increased risk of dementia. However, it remains unclear whether the risk relates to short or long half-life benzodiazepines and whether it extends to other psychotropic drugs.Methods: Prospective cohort study among 8240 individuals >= 65, interviewed on medication use. Incident dementia confirmed by an end point committee after a multistep procedure.Results: During a mean of 8 years of follow-up, 830 incident dementia cases were observed. Users of benzodiazepines at baseline had a 10% increased risk of dementia (adjusted hazard ratio [HR], 1.10; 95% confidence interval, 0.90-1.34). However, long half-life (>20 hours) benzodiazepine users had a marked increased risk of dementia (HR = 1.62; 1.11-2.37) compared with short half-life users (HR = 1.05; 0.85-1.30). Users of psychotropics had an increased risk of dementia (HR = 1.47; 1.16-1.86).Discussion: Results of this large, prospective study show increased risk of dementia for long half-life benzodiazepine and psychotropic use. (C) 2015 Alzheimer's Association. Published by Elsevier Inc. All rights reserved.