A MODEL OF THE GENERATION OF THE COCHLEAR MICROPHONIC WITH NONLINEAR HAIR CELL TRANSDUCTION AND NONLINEAR BASILAR-MEMBRANE MECHANICS

A MODEL OF THE GENERATION OF THE COCHLEAR MICROPHONIC WITH NONLINEAR HAIR CELL TRANSDUCTION AND NONLINEAR BASILAR-MEMBRANE MECHANICS
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DOI:
10.1016/0378-5955(87)90185-7
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发表时间:
1987-01-01
期刊:
影响因子:
2.8
通讯作者:
PATUZZI, RB
PATUZZI, RB
中科院分区:
医学1区
文献类型:
--
作者:
PATUZZI, RB

文献摘要

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本文提出了豚鼠耳蜗微音管萌发的现象学模型,该模型包含了耳蜗区振动的尖锐调谐和非线性生长,以及由单个线性毛细胞阵列(假设为外毛细胞)对这种反应的非线性传递。还假设每个毛细胞发生器对微音器电势的贡献随着距离毛细胞的距离呈指数衰减。使用实验获得的参数估计值,理论微音调谐曲线与生长函数之间获得了很好的一致性,而不依赖于耳蜗区的复杂微机械运动、毛细胞的电调或耳蜗内毛细胞的贡献。
A phenomenological model of the germination of the cochlear microphonic of the guinea pig is presented which incorporates sharp tuning and nonlinear growth of the vibration of the cochlear partition, and nonlinear transduction of this response by a single linear array of hair cells (assumed to be the outer hair cells). The contribution to the microphonic potential from each hair cell generator is also assumed to decay exponentially with distance from the hair cell. Using experimentally obtained estimates for the parameters a good agreement between the theoretical microphonic tuning curves and growth functions was obtained without recourse to complex micromechanical motion of the cochlear partition, electrical tuning of the hair cells or a contribution from the inner hair cells of the cochlea.