Lateral membrane waves constitute a universal dynamic pattern of motile cells
Lateral membrane waves constitute a universal dynamic pattern of motile cells
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DOI：
10.1103/physrevlett.97.038102
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发表时间：
2006-07-21
影响因子：
8.6
通讯作者：
Sheetz, Michael P.
中科院分区：
文献类型：
--
作者：
Doebereiner, Hans-Guenther;Dubin-Thaler, Benjamin J.;Sheetz, Michael P.
我们已经监测了多种细胞在特定涂层底物上细胞周长的主动运动，包括小鼠胚胎成纤维细胞和T细胞，以及果蝇的翼盘细胞。尽管这些细胞具有不同的功能和来自不同的门，但它们在正常的膜速度上具有共同的时空模式；我们发现，突起和收缩事件是沿细胞膜的侧波组织的。这些波形显示了肌动球蛋白凝胶在空间和时间上的长期周期性相关性。
We have monitored active movements of the cell circumference on specifically coated substrates for a variety of cells including mouse embryonic fibroblasts and T cells, as well as wing disk cells from fruit flies. Despite having different functions and being from multiple phyla, these cell types share a common spatiotemporal pattern in their normal membrane velocity; we show that protrusion and retraction events are organized in lateral waves along the cell membrane. These wave patterns indicate both spatial and temporal long-range periodic correlations of the actomyosin gel.