Mitochondria and the aging heart.
Mitochondria and the aging heart.
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DOI：
10.3724/sp.j.1263.2011.00159
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发表时间：
2011-09
期刊：
影响因子：
--
通讯作者：
Seubert JM
中科院分区：
文献类型：
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作者：
Chaudhary KR;El-Sikhry H;Seubert JM
在现代社会中，人类的平均寿命显著延长，这主要归功于医学和治疗科学的进步，这些科学成功地减少了重要的健康风险。然而，高龄导致细胞和亚细胞成分的许多改变，这些改变可能影响个体的整体健康和功能。毫不奇怪，高龄是发生心脏病的主要危险因素，老年人的发病率和死亡率增加。即使是在休息条件下心脏功能似乎正常的健康人，实际上也会增加对压力的易感性和脆弱性。这是混淆的影响，压力和疾病可以随着时间的推移对心脏和血管。尽管有大量文献研究衰老对心脏的影响以及年龄相关的改变如何影响心脏功能，但衰老的生物学和潜在机制仍不清楚。在这篇综述中，我们总结了衰老对心脏的影响，并讨论了细胞衰老的潜在理论，特别强调线粒体功能障碍。
The average human life span has markedly increased in modern society largely attributed to advances in medical and therapeutic sciences that have successfully reduced important health risks. However, advanced age results in numerous alterations to cellular and subcellular components that can impact the overall health and function of an individual. Not surprisingly, advanced age is a major risk factor for the development of heart disease in which elderly populations observe increased morbidity and mortality. Even healthy individuals that appear to have normal heart function under resting conditions, actually have an increased susceptibility and vulnerability to stress. This is confounded by the impact that stress and disease can have over time to both the heart and vessels. Although, there is a rapidly growing body of literature investigating the effects of aging on the heart and how age-related alterations affect cardiac function, the biology of aging and underlying mechanisms remain unclear. In this review, we summarize effects of aging on the heart and discuss potential theories of cellular aging with special emphasis on mitochondrial dysfunction.