The roles of vasoactive intestinal polypeptide in the mammalian circadian clock
The roles of vasoactive intestinal polypeptide in the mammalian circadian clock
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DOI：
10.1677/joe.0.1770007
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发表时间：
2003-04-01
影响因子：
4
通讯作者：
Cutler, DJ
中科院分区：
文献类型：
--
作者：
Piggins, HD;Cutler, DJ
内源性周期接近 24 小时（昼夜节律）的生物振荡是由位于下丘脑视交叉上核 (SCN) 的主昼夜节律起搏器或时钟产生的。该时钟与选择性神经通路传递的重复环境信号同步。 SCN神经元的主要化学成分之一是血管活性肠多肽（VIP）。这些神经元是视网膜受体并被光激活。在体内和体外，外源性应用 VIP 都会以类似光的方式重置 SCN 生物钟。这些重置作用似乎是通过 VPAC(2) 受体（VIP 受体的一种）介导的。出乎意料的是，VPAC(2) 受体的基因表达消融导致生物钟在分子、神经生理学和行为水平上出现心律失常。这些发现表明，这种通过 VPAC(2) 受体发挥作用的内在神经肽参与光重置和 SCN 持续节律性的维持。
Biological oscillations with an endogenous period of near 24 h (circadian rhythms) are generated by the master circadian pacemaker or clock located in the suprachiasmatic nuclei (SCN) of the hypothalamus. This clock is synchronised to recurring environmental signals conveyed by selective neural pathways. One of the main chemical constituents of SCN neurones is vasoactive intestinal polypeptide (VIP). Such neurones are retino-recipient and activated by light. Exogenous application of VIP resets the SCN circadian clock in a light-like manner, both in vivo and in vitro. These resetting actions appear to be mediated through the VPAC(2) receptor (a type of receptor for VIP). Unexpectedly, genetically ablating expression of the VPAC(2) receptor renders the circadian clock arrhythmic at the molecular, neurophysiological and behavioural levels. These findings indicate that this intrinsic neuropeptide acting through the VPAC(2) receptor participates in both resetting to light and maintenance of ongoing rhythmicity of the SCN.